Antidotes: Principles and Clinical ApplicationsNo abstract is available for this article.doi:10.1046/j.1365-2125.2003.01856.xR. E. FernerJohn Wiley & Sons, Ltd (10.1111)British Journal of Clinical Pharmacology
life-threatening event of limited duration. There is a paucity of experimental or clinical evidence supporting the superiority of monotherapy in the treatment of acute seizures and SE. There is also no consensus on the criteria which allow comparisons between the benefits and adverse effects of mono...
The global burden of heavy metal especially mercury, arsenic, lead, and cadmium toxicities remains a significant public health challenge. Developing nations are particularly at high risk and carry the highest burden of this hazard. Chelation therapy has been the mainstay for treatment of heavy metal...
Clinical applications of commonly used contemporary antidotes. Bowden CA,Krenzelok EP. Drug Safety . 1997Bowden CA, Krenzelok EP. Clinical applications of commonly used contemporary antidotes: a US perspective. Drug Saf 1997; 16: 9–47Krenzelok EP. Clinical Applications of commonly used contemporary...
"With the ever-increasing number of such drugs in clinical trials, we believe that this discovery can have very broad applications and improve the safety profile of these therapeutics," Oney said. "This could be rapidly translated into the clinic, and lead to a whole new class of safer thera...
Over the past 25 years, aptamers have gained clinical interest due to their several unique characteristics. Aptamers are short single-stranded oligonucleotides which can fold into three-dimensional structures. These molecules can bind with a high affinity and specificity to the target of interest [1]...
A phase III clinical trial for recurrent GBM failed due to no significant difference in progression-free survival for monotherapy or combination treatments [43]. Clinical trial outcomes could be improved by using an encapsulated form of the drug to extend the circulation time in the body and ...