and an antidote that works immediately - because the blood thinner and antidote were designed to work together. Researchers at Duke University Medical Center have engineered a way to do this for an entire, versatile class of drugs called aptamers and published their findings inNature Medicine....
Improving Patient Care By Designing Drugs And Their Antidotes TogetherImproving Patient Care By Designing Drugs And Their Antidotes Together - Medical News TodayNature Medicine
In addition to supportive treatment, two antidotes are of benefit, atropine and oximes. Atropine is given in boluses until the full antimuscarinic effect is obtained (i.e. red dry skin, dilated pupils, heart rate >80 beats min−1). An infusion of atropine might be required for resistant...
Narcan works to block the opioid effect as it is an opioid antagonist as it competes for the opiate receptors in the brain and other areas of the body to help reverse the dangerous effects of theopioidso that the patient's breathing improves and they become more awake, and their blood pres...
Advise women to inform their clinician if they are or plan to become pregnant or plan to breast-feed. Breast-feeding women may consider pumping and discarding their milk for 30 hours after administration. Advise patients to inform their clinician of existing or contemplated concomitant therapy, incl...
Certain antidotes, which are designed to act specifically on some of the anticoagulants, have been granted the new technology add-on payment (NTAP) status by the U.S. Centers for Medicare and Medicaid Services (CMS). The status increases patient access to drugs by providing additional Medicare...
Features and properties of andexanet alfa [coagulation factor Xa (recombinant), inactivated-zhzo] Alternative names AndexXa; AnXa; IndexXa; PRT-064445; PRT-4445; PRT-44545; recombinant factor-Xa-Portola; rfXa-inhibitor-antidote Class Antidotes; antihaemorrhagics; disulfides; recombinant proteins ...
agents that result in QT prolongation and the corresponding potential for torsades de pointes, as well as unique features encountered with the various medications are discussed. The diagnosis of this overdose is largely based on history. Routine use of drug screens is unlikely to be beneficial. The...
Patients undergoing cardiac surgery with cardiopulmonary bypass (CPB) experience transient haemostatic defects as a result of adverse changes to their blood components, blood cells and specific coagulation proteins. Aprotinin is a naturally occurring serine protease inhibitor isolated from bovine lung tissue...
Oncolytic viruses have demonstrated very tolerable safety profiles, and their ability to modulate the tumour microenvironment provides a rational strategy for combination treatment with other cancer agents to improve therapeutic responses. Oncolytic viruses can easily be combined with a wide range of therapi...