The therapeutic application of zinc sulphate as an antidote to acetaminophen overdose was examined in ICR mice. Hepatotoxicity was induced by a single oral dose of acetaminophen (750 mg/kg). Various treatments (normal saline, 15 or 30 mg/kg zinc sulphate, 150 mg/kg N -acetylcysteine, 15 mg...
Stratification of paracetamol overdose patients using new toxicity biomarkers: current candidates and future challenges. One of the most common causes of acute liver failure in the Western world is paracetamol (acetaminophen) overdose. Specific and sensitive detection of live... James,W,Dear,... - ...
A short cut review was carried out to establish whether there was any evidence to decide between oral or intravenous antidote in paracetamol (acetaminophen) poisoning. Altogether 330 papers were found using the reported search, of which two presented the best evidence to answer the clinical question...
A short cut review was carried out to establish whether there was any evidence to decide between oral or intravenous antidote in paracetamol (acetaminophen) poisoning. Altogether 330 papers were found using the reported search, of which two presented the best evidence to answer the clinical question...
Context. Haemodialysis is sometimes used for patients with massive acetaminophen overdose when signs of "mitochondrial paralysis" (lactic acidosis, altered mental status, hypothermia and hyperglycaemia) are present. The role of haemodialysis is debated, in part because the evidence base is weak and the...
N-acetylcysteine (NAC), a GSH precursor, is the only currently approved antidote for an acetaminophen overdose. Unfortunately, fairly high doses and longer treatment times are required due to its poor bioavailability. In addition, oral and I.V. administration of NAC in a hospital setting are ...
Context. Haemodialysis is sometimes used for patients with massive acetaminophen overdose when signs of "mitochondrial paralysis" (lactic acidosis, altered mental status, hypothermia and hyperglycaemia) are present. The role of haemodialysis is debated, in part because the evidence base is weak and the...
Antidote removal during haemodialysis for massive acetaminophen overdose. Clin Toxicol ( Phila) ,2013,51(9) :855⁃863.Sivilotti MLA, et al. Antidote removal during haemodialysis for massive acetaminophen overdose. Clinical Toxicology 51: 855-863, No. 9, Nov 2013. Available from: URL: http:/...
First parenteral antidote approvedDRUG approvalLIVERACETAMINOPHENDRUGS -- OverdoseUNITED States. Food & Drug AdministrationReports on the U.S. Food and Drug Administration's approval of acetylcysteine to prevent or lessen liver damage from an acetaminophen overdose.Nursing...
1. The combined antidote effect of N-acetylcysteine and ethanol on the toxicity of acetaminophen was investigated. 2. Fed male mice were given acetaminophen i.p. (600 mg kg-1) and after 5 min in addition ethanol i.p. (0.2 ml, 19% v/v), N-acetylcysteine i.p. (1.2 g kg-1, 0.2...