Acetaminophen (N-acetyl-p-aminophenol, APAP) is one of the most widely used over the counter antipyretic and analgesic medications. It is safe at therapeutic doses, but its overdose can result in severe hepatotoxicity, a leading cause of drug-induced acute liver failure in the USA. Depletion ...
Stratification of paracetamol overdose patients using new toxicity biomarkers: current candidates and future challenges. One of the most common causes of acute liver failure in the Western world is paracetamol (acetaminophen) overdose. Specific and sensitive detection of live... James,W,Dear,... - ...
It is concluded that both drugs attenuate acetaminophen-induced hepatic toxicity, and the action is likely to be mediated through replenishment of hepatic glutathione levels. The use of zinc sulphate alone or in combination with N -acetylcysteine could be another alternative for the treatment of ...
Thymoquinone could be used as a potential treatment for toxic cardiomyopathy [21]. 5.1.4. Paracetamol-Induced Hepatotoxicity Nigella sativa offers protection against paracetamol-induced liver damage and nephrotoxicity [22] and has effects on hepatotoxicity and oxidative stress caused by acetaminophen. The...