抗体依赖的细胞吞噬功能测试(Antibody Dependent Cellular Phagocytosis, ADCP) 基于抗体的疗法是已被证明是治疗疾病的一种有效途径。通过将Fc区与免疫细胞表面上的FcγR结合,抗体可使一些效应细胞产生较强的细胞毒性作用,除了ADCC,还有抗体依赖性的细胞吞噬作用(ADCP)。 ADCP是一种通过抗体同时结合于靶细胞(如肿瘤细胞)...
In recent years, Fc‐receptor‐dependent antibody effector functions, particularly, antibody‐dependent cellular phagocytosis (ADCP) were shown to offer immune protection against several RNA viruses. However, its development and clinical role in patients with HCV infection remain unknown. In this study,...
Antibody-dependent cell-mediated cytotoxicity (ADCC) and antibody-dependent erythrophagocytosis (ADEP) of peripheral blood leukocytes in patients with Sjog... 市川幸延 - 《岡山医学会雑誌》 被引量: 0发表: 1979年 PHA-induced and antibody dependent cell-mediated cytotoxicity in patients with various...
How to cite this article:Liu, Q.et al. Antibody-dependent-cellular-cytotoxicity-inducing antibodies significantly affect the post-exposure treatment of Ebola virus infection.Sci. Rep.7, 45552; doi: 10.1038/srep45552 (2017). Publisher's note:Springer Nature remains neutral with regard to jurisdicti...
B Introduction: b Anti-CD20 monoclonal antibodies (mAbs) have revolutionized the treatment of B-cell lymphomas (BCL). Degradation of CD47-SIRP axis by pomalidomide potentiates CD20 antibody-dependent cellular phagocytosis against B-cell lymphoma Pomalidomide (Pom) is more powerful than ...
CR3-blocking mAbs have been shown to inhibit CR3-mediated signaling and phagocytosis of effector cells.25, 26, 27 We used blocking mAbs to CD11b and CD18 to investigate whether the ability of complement to inhibit NK activation is through CR3. The inhibitory effects of human serum on ...
Watanabe M, Wallace PK, Keler T, Deo YM, Akewanlop C, Hayes DF: Antibody dependent cellular phagocytosis (ADCP) and antibody dependent cellular cytotoxicity (ADCC) of breast cancer cells mediated by bispecific antibody, MDX-210. Breast Cancer Res Treat. 1999, 53: 199-207. 10.1023/A:100614550...
The appearance of soluble radioisotope from macrophages (M phi) that previously had ingested 51Cr-labelled antibody-coated sheep erythrocytes (51Cr-EA) was assessed to determine if exocytosis contributed to the pool of radioactivity used to measure antibody-dependent cellular cytotoxicity (ADCC). M ph...
By engaging with Fc纬RIIIA (CD16), Elo promotes potent NK cell-mediated antibody-dependent cellular cytotoxicity (ADCC) and macrophage-mediated antibody-dependent cellular phagocytosis (ADCP) toward SLAMF7+ MM tumor cells. Relapsed/... T Pazina,AM James,KB Colby,... - 《Cancer Immunology Res...
A. et al. Inter-cellular CRISPR screens reveal regulators of cancer cell phagocytosis. Nature 597, 549–554 (2021). Article CAS Google Scholar Yang, X. et al. Cetuximab-mediated tumor regression depends on innate and adaptive immune responses. Mol. Ther. 21, 91–100 (2013). Article CAS...