抗体依赖的细胞吞噬功能测试(Antibody Dependent Cellular Phagocytosis, ADCP) 基于抗体的疗法是已被证明是治疗疾病的一种有效途径。通过将Fc区与免疫细胞表面上的FcγR结合,抗体可使一些效应细胞产生较强的细胞毒性作用,除了ADCC,还有抗体依赖性的细胞吞噬作用(ADCP)。 ADCP是一种通过抗体同时结合于靶细胞(如肿瘤细胞)...
T-DM1具有细胞外肿瘤杀伤机制,比如ADCC和ADCP(antibody-dependent cell-mediated phagocytosis)。与此不同的是,被FDA批准的另一ADC药物brentuximab vedotin,作用于多种淋巴细胞增殖的疾病,这是CD30抗体,只显示针对间变性大细胞淋巴瘤(anaplastic large-cell lymphoma ALCL) 肿瘤有中等细胞外肿瘤杀伤机制,其血液肿瘤细胞则...
补体依赖的细胞毒性作用(Complement Dependent Cytotoxicity,CDC)或抗体依赖的细胞吞噬作用(Antibody Dependent Cellular Phagocytosis,ADCP)一般不是 ADC产品的主要作用机理但可能也有一定的作用效力,应基于抗体的类型、结构改造等开展Fc功能研究,若对终产品的安全性或有效性产生影响,则应进行适当的控制。
T-DM1具有细胞外肿瘤杀伤机制,比如ADCC和ADCP(antibody-dependent cell-mediated phagocytosis)。与此不同的是,被FDA批准的另一ADC药物brentuximab vedotin,作用于多种淋巴细胞增殖的疾病,这是CD30抗体,只显示针对间变性大细胞淋巴瘤(anaplastic large-cell lymphoma ALCL) 肿瘤有中等细胞外肿瘤杀伤机制,其血液肿瘤细胞则...
A method of regulating antibody-dependent cellular cytotoxicity (ADCP) activity of an antibody composition is provided herein. In an exemplary embodiment, the method comprises (a) galactosylated glycans of the antibody, (b) non-fucosylated glycans of the antibody, (c) high mannose glycans of the ...
antibody-dependent cellular phagocytosis (ADCPcomplement-dependent cytotoxicity (CDCFc-gamma receptor (FcγRmonoclonal antibody (mAbneonatal Fc receptor (FcRnAntibody-based drugs are one of the largest and fastest growing therapeutic platforms for use in a diverse number of diseases. Currently, the ...
functions through, for example, single point mutations, glycoengineering, Thiomab technology or the incorporation of unnatural amino acids.ADCC, antibody-dependent cellular cytotoxicity;ADCP, antibody-dependent cellular phagocytosis;CDC, complement-dependent cytotoxicity;MAC, membrane attack complex;NK, natural...
IgG3 and IgG4. IgG1 the commonly used subtype for ADCs as IgG1 is the most abundant in serum and could induce the strong effector functions such as antibody-dependent cell-mediated cytotoxicity (ADCC), antibody dependent phagocytosis (ADCP), and complement dependent cytotoxicity (CDC) by a hig...
Antibody-dependent cell-mediated cytotoxicity (ADCC). The killing of infected cells by effector cells (for example, natural killer cells) via bound antibody. Antibody-dependent cellular phagocytosis (ADCP). The phagocytosis of infected cells or virus by effector cells (for example, macrophages) via ...
[1]. BisAbs with no Fc, such as tandem scFv,diabodies, DARTs, scFv-CH1/CL-scFv, Fab-scFv, Fab-Fv, and many other formats, lack Fc-mediated effector functions, such as antibody-dependent cell-mediated cytotoxicity (ADCC), antibody-dependent cellularphagocytosis(ADCP), complement-dependent ...