Background:Protein A is a 40-60 kDa surface protein originally found in the cell wall of the bacteria Staphylococcus aureus (SPA). SPA binds proteins from many of mammalian species, most notably IgGs, and helps inhibit phagocytic engulfment and acts as an immunological disguise via this type ...
The HPV virion is a highly ordered structure whose major protein is L1 and when expressed in eukaryotic cells, results in the formation of VLPs that elicit HPV-neutralizing antibodies. Bivalent, quadrivalent, and nonavalent HPV vaccines have been shown to be highly effective and have been licensed...
Protein A binds to the constant region of many species of immunoglobulin G. Protein A can be used to detect,quantify and purify IgG antibodies and antibody/antigen complexes. Protein A binds to all IgG subclasses from human and mouse species.
To detect new antigen candidates for serological tests, we studied the antibody response to pneumococcal protein antigens in mice infected intratracheally with various Streptococcus pneumoniae strains. Sera were tested by Western blotting against whole-cell protein extracts. Mice developed a detectable imm...
SHP-1 (PTPN6) is a non-receptor protein tyrosine phosphatase that is expressed primarily in hematopoietic cells. The enzyme is composed of two SH2 domains, a tyrosine phosphatase catalytic domain, and a carboxy-terminal regulatory domain. SHP-1 removes phosphates from target proteins to downregulat...
making tumour destruction possible. Similar effects have been achieved with inhibitors ofprogrammed cell death1 (PD-1), a protein expressed on the surface of T cells that negatively regulatesT cellactivity and that is overexpressed in many cancers. Anti-PD-1 therapies, such as nivolumab and pembr...
It is synthesized in response to inflammatory stimuli as a 31 kDa inactive pro-form that accumulates in the cytosol. Cleavage of pro-IL-1 beta into the active 17 kDa protein requires the activation of inflammasomes, which are multi-protein complexes that respond to pathogens, str...
Fine tuning of an antibody binding site by mutagenesis and phage display : Ari Hemminkia, Seija Niemib, Leena Hakalahtib, Hans Söderlunda, Kristiina Tak... High-grade serous ovarian cancer (HGSOC) is the most common and difficult to treat ovarian cancer subtype. HGSOC is diagnosed typica...
TSPAN10 is a membrane protein of the tetraspanin superfamily, which are characterized by the presence of four conserved transmembrane regions. Tetraspanins have been involved in diverse processes such as cell activation and proliferation, adhesion and motility, differentiation, and cancer. TSPAN10 belongs...
Galanin is a neuroendocrine peptide that is widely expressed in the central and peripheral nervous systems and also the gastrointestinal tract, pancreas, adrenal gland and urogenital tract. The encoded protein is a precursor that is proteolytically processed to generate two mature peptides: galanin and...