Our approach allowed the consistent identification of characteristic SARS-CoV-2-mutations within the Spike coding region that provide resistance to four different therapeutic antibodies, Bamlanivimab, Bebtelovimab, Cilgavimab and Sotrovimab, and two broadly-neutralizing antibodies, S2K146 and S2H97. Th...
Identification of APS means that many patients who were in the past diagnosed as suffering from a "vasculitis" and treated with anti-inflammatory regimes and high-dose corticosteroids, will, if found to be suffering from APS, respond better to anti-coagulation therapy (GP Notebook, 2001). First...
Results ATV enhances brain exposure and activity of a TREM2 antibody A mouse TREM2-specific antibody, 4D9, was previously shown to enhance protective microglial functions and reduce amyloid pathology in an AD mouse model31. To evaluate ATV technology, we generated ATV:4D9 on a human IgG backb...
After identification of public clonotypes, they were plotted in a Circos plot using the R package circlize (Gu et al., 2014). Identification of 18 strongly neutralizing antibodies To identify the most potent SARS-CoV-2 neutralizing mAb, all 122 S1-reactive mAbs were screened for binding to ...
Identification of a Novel Autoantibody Reactive with 155 and 140-kDa Nuclear Proteins in Patients with Dermatomyositis: An Association with Malignancy. Rheumatology 2007, 46, 25–28. [Google Scholar] [CrossRef] [Green Version] Hatakeyama, S. TRIM Proteins and Cancer. Nat. Rev. Cancer. 2011, ...
Residue numbering schemes evolved in parallel with the CDR identification and aimed at the correct positioning of insertions and deletions in the antigen-binding loops. Since the Chothia numbering scheme [32] was based on structural considerations, it represents the best choice and is widely used in...
toxins Article Characterization of Chicken-Derived Single Chain Antibody Fragments against Venom of Naja Naja Atra Chi-Hsin Lee 1,†, Sy-Jye Leu 2,3,†, Yu-Ching Lee 4, Chia-I Liu 1, Liang-Tzung Lin 2,3, Pharaoh Fellow Mwale 1, Jen-Ron Chiang 5 , Bor-Yu Tsai 6, Chi-Ching ...