2.2Mechanism of action of antibody-drug conjugates Most ADCs are designed to target specific internalizing antigens, such as surface receptors, with subsequent internalization of the ADCs, intracellular cleavage of the linker, and subsequent direct release of the drug in the tumor cells to elicit cyt...
Fig. 1.Mechanism of action of antibody–drug conjugates. (FromNagayama, Aiko, Leif W. Ellisen, Bruce Chabner, and Aditya Bardia. 2017. “Antibody–Drug Conjugates for the Treatment of Solid Tumors: Clinical Experience and Latest Developments.” Targeted Oncology 12 (6): 719–39.) ...
Target antigen binding activityRelated pharmacology of target antigen (e.g.: ADCC,CDC)Mechanism of payloads and metabolites (focus on the difference in pharmacology mechanism ADCs, naked antibodies,payload and metabolites). Effects of the free small molecule compounds after internalization, disassembly ...
Antibody–drug conjugates (ADCs) are a relatively new class of anticancer agents designed to merge the selectivity of monoclonal antibodies with cell killing properties of chemotherapy. They are commonly described as the “Trojan Horses” of therapeutic armamentarium, because of their capability of direc...
et al. Engineered cysteine antibodies: an improved antibody-drug conjugate platform with a novel mechanism of drug-linker stability. Protein Eng. Des. Sel. 31, 47–54 (2018). Article CAS PubMed Google Scholar Kovtun, Y. et al. A CD123-targeting antibody-drug conjugate, IMGN632, designed...
ADC 抗体药物偶联物Antibody Drug Conjugate通过化学链接将具有生物活性的小分子药物连接到单抗上产生的药物,单抗作为载体将小分子药物靶向运输到目标细胞中 PROTACS蛋白水解靶向嵌合體Proteolysis-Targeting Chimeras 蛋白水解靶向嵌合体(Proteolysis-Targeting ChimerasPROTACS)技术作为一种新的治手段,在抗肿瘤物领域中得到了广泛...
This, as well as the chemistry of the drug, can dictate whether the drug can diffuse into surrounding cells, resulting in 'bystander killing'. Initially, any bystander killing mechanism of action of an ADC was understood to involve an essential sequence of steps beginning with surface antigen ...
【ADC药物作用机理】 1)抗体偶联药物(ADC,Antibody-drugconjugate)是将单克隆抗体药物的高特异性和小分子细胞毒药物的高活性相结合,用以提高肿瘤药物的靶向性、减少毒副作用。与传统的完全或部分人源化抗体或抗体片段相比,ADC因为能在肿瘤组织内释放高活性的细胞毒素
Mechanism of action of antibody-drug conjugates From a nanomedical standpoint, ADCs work as self-targeting nanoscale carriers (Fig. 1) [9]. These immunoconjugates overcome the limitations of traditional synthetic nanodrugs such as lack of delivery to target cells, low cellular internalization and high...
Mechanism of action of an ADC. Today, ADCs have yet to live up to their expected clinical potential, and it is anticipated that a better understanding of the mechanisms of ADC toxicity and efficacy will help in the design of better drugs and improve clinical design, resulting in reduced ...