超变区(hyper-variable region,HVR),又称互补决定区(complementary determining region,CDR) 骨架区(framework region,FR) 铰链区(hinge region) 1、轻链重链 IgM 、IgD 、IgG 、IgA 和IgE 相应的重链分别为μ 链、δ链、γ链、α 链和ε 链。同一类Ig ,根据其铰链区氨基酸组成和重链二硫键的数目和位置的差...
According to the IgG2 antibody provided by the invention, the heterogeneity caused by disulfide bonds in the hinge region of the antibody is eliminated, and the effect of improving the antiprotease hydrolysis effect is achieved.李强李媛丽孙见宇...
抗原:Purified human IgG3 myeloma protein物种:人宿主:小鼠抗体亚型:IgG克隆号:HP6050荧光染料:其它加入购物车 产品介绍 技术参数 相关产品 产品介绍 类型: 单抗 同型对照: 浓度: 1 mg/mL 用法: Assay dependent(ELISA);10 µL for 10^6 cells in 100 µL (Flow);Assay dependent (IHC (F)) ...
重链 V 区(VH)和轻链 V 区(VL)各有 3 个区域 的氨基酸组成和排列顺序高度可变,称为高变区(hypervariable region,HVR);因 该区域形成与抗原表位互补的空间构象,又被称为互补决定区(complementarity determining region,CDR),分别用 CDR1(HVR1)、CDR2(HVR2)和 CDR3(HVR3) 表示,一般 CDR3 变化程度更高。VH...
抗体（Antibody，Ab）是存在于动物血清中的一类由浆细胞分泌的具有免疫学功能的球形糖蛋白。能特异性与抗原结合，从而引发一系列的免疫学效应。抗体是体液免疫应答的主要产物，也称为免疫球蛋白（immunoglobulin，Ig)。albuminglobulin γ-球蛋白组分：IgG———主要抗体类型β-球蛋白组分：IgM、IgA、IgE、IgDα2-球蛋...
6、区(CH) 重链铰链区(重链铰链区(Hinge region) 富含脯氨酸,增强捕捉抗原的强度,对蛋白酶敏感。富含脯氨酸,增强捕捉抗原的强度,对蛋白酶敏感。IgMIgM和和IgEIgE无铰链区。无铰链区。l结构域(结构域(domains) Ig分子的每条肽链均可由链内二硫键折叠为几个分子的每条肽链均可由链内二硫键折叠为几个球形的环...
An IgG antibody is composed of two antigen-binding Fab domains that are linked by a flexible hinge region to a glycosylated Fc domain that mediates immunological functions (Benucci, Saviola, Manfredi, Sarzi-Puttini, & Atzeni, 2012). From: Pharmacology & Therapeutics, 2016 ...
Impact of IgG architecture on E104 activity We next sought to identify the molecular features of the IgG architecture required for activity. Given that Fc-mediated effects are likely not required for inhibition, we focused our attention on the hinge region of the antibody. This region serves as...
产品类型:荧光二抗 品牌:Thermo Fisher 货号:MA5-27935 规格:50 µg 价格:3994 抗原:Peptide corresponding to the hinge region of Human 物种:人 宿主:兔 抗体亚型:IgG 克隆号:RM120 荧光染料:Biotin 产品介绍 技术参数 相关产品 产品介绍 类型:
CD23 interacts with IgE-Fc at the hinge region between Cε3 and Cε4 domains (Fig.2j), favoring a closed conformation of Cε3 domains34. Comparison of the CD23 and ligelizumab interaction sites on IgE indicates relatively minor overlap between binding sites of these two IgE ligands (Fig...