Antibodiesare special protein molecules that the immune system produces in response to antigens. Andantigensare substances that can stimulate the body’s production of antibodies. Now, there are different types of antigens, but, for our purposes here, let’s zoom in on foreign, disease-causing ...
[2] until today, an extraordinary scientific work has been put forth, enabling the clinical translation of monoclonal antibodies and antibody-based therapeutics for patients with unresolved clinical needs. Antibodies are a soluble form of B cell receptors (BCRs) and are essential molecules of the h...
Future work will look to develop large-scale photoconjugation and purification of fully blocked cetuximab molecules from those with one light chain left un-conjugated. This will produce uniform cetuximab conjugates with much lower affinities before activation with light or protease treatment. Methods ...
Adenoviruses are a DNA containing viruses featuring an icosahedron-shaped particle formed by hexon, penton, and fibril proteins. Each virus particle contains 12 molecules of penton and fibril proteins that carry type-specific antigens. Variability of the latter do not permit useful mAbs to be produc...
Organic molecules absorb mid-infrared light of specific frequencies, resulting in highly individual infrared spectra giving each species a distinct chemical footprint. The fact that positions of the amide bands in infrared spectra are dependent on the protein secondary struc- ture is particularly ...
The finding, published on Monday in the journal Proceedings of the National Academy of Sciences, suggested that aptamers, lab-made molecules that function like antibodies, could form the basis of new cancer therapies if additional studies in animals and humans bear out. ...
The antibodies tested in the present study target the NA active site directly, which makes it possible to use the NA-Star assay for the determination of NAI. Typically, the NA-Star kit is used to detect resistance to neuraminidase inhibitors (e.g. small molecules). The NA-Star Influenza ...
Synthetic carbohydrate haptens, which are conjugated to carrier human serum albumin molecules [synthetic tumor-associated glycoconjugates (S-TAGs)], were used to immunize mice for monoclonal antibody (MoAb) production. Two of the S-TAGs were composed of haptens related to the Thomsen-Friedenreich (...
Epitope--A structural component of an antigen molecule known to function as an antigenic determinant by allowing the attachment of certain antibody molecules. Erythrocyte--The mature hemoglobin containing cell of vertebrate blood; non-nucleated in mammals, the equivalent cell is nucleated in birds. ...
The precursor of filaggrin, profilaggrin, consists essentially of repeated domains of filaggrin; this results in a close immunological relationship between these two molecules for a review on filaggrins, see DALE et al. Cellular and Molecular Biology of Intermediates Filaments, pp. 393-412, GOLDMAN...