Insulin resistance may occur in a large number of different disease states. The most frequent causes of mild to moderate insulin resistance are obesity and maturity-onset, insulin-independent diabetes (Olefsky, 1981). This chapter will consider two of the rare forms of insulin resistance: the ...
These insulin antibodies are present in a large percentage of newly diagnosed, untreated diabetics and may be an immune marker of B-cell damage. 展开 关键词: insulin carbohydrate metabolism hormones proteins diabetes mellitus antibodies DOI: 10.1126/science.6362005 被引量: 2427 ...
The antibody and part of the antigen are specifically associated with the smimar growth factor receptor and insulin-1 (IGF-IR), which is the best human IFF factor. The invention also relates to human anti ifg-ir antibodies, including cosmetic antibodies, double antibodies, separators, single ...
Cancer and other diseases are multifactorial, with many signaling pathways implicated in pathogenesis. Single-target immunotherapy does not seem to destroy cancer cells sufficiently. Bispecific antibodies (BsAbs) have been posited as potential cancer therapeutic agents for decades but have only recently ...
Insulin therapies – past, present and future - ScienceDirect The discovery of insulin is one of the greatest milestones in medical history. This discovery revolutionized the use of peptides and proteins as therapeuti... O Pillai,R Panchagnula - 《Drug Discovery Today》 被引量: 179发表: 200...
Technology for displaying a protein, such as an antibody fragment, on the surface of a bacteriophage that contains the gene (or genes) encoding the displayed protein (or proteins), thereby physically linking the genotype and phenotype. Binding affinity For two interacting molecules this is the rati...
: Insulin-Precipitating Antibodies in Insulin-Treated and Untreated Diabetic Patients - Diabetologia4, 164, 1968. Article PubMed CAS Google Scholar Reisfeld R. A., Lewis U. J., Williams D. E.: Disk Electrophoresis of Basic Proteins and Peptides on Polyacrylamide Gels - Nature (Lond.)195, ...
The term bispecific antibody (bsAb) is used to describe a large family of molecules designed to recognize two different epitopes or antigens. BsAbs come in many formats, ranging from relatively small proteins, merely consisting of two linked antigen-bind
Comparing the antibody responses against recombinant hemagglutinin proteins of avian influenza A (H5N1) virus expressed in insect cells and bacteria The hemagglutinin (HA) of influenza A virus plays an essential role in mediating the entry of the virus into host cells. Here, recombinant full-length...
correlated proteins31. The obtained Pearson's correlation co-efficient between LRP/LR and the AD relevant proteins are all approximately within the 0.9 range (Table 1). An alternative laminin binding receptor, Very Late Antigen 6 (VLA6), employed as a negative control failed to co-localise ...