The incidence of antimicrobial resistance has been increasing worldwide in the past decades, which includes resistance to bacteria that cause common childhood illnesses, such as acute respiratory infections and diarrhea. Numerous children with those comm
21 A second phase of interest was initiated when CTW was the CEO of the Dana Farber Cancer Institute in the early 1990s at a time when vancomycin was being used as the antibiotic of last resort for treatment of life-threatening Gram-positive bacterial infections of patients under- going ...
Objective Infections from penetrating brain injuries (PBI) lead to higher morbidity and mortality rates. The results of this research will be evaluated to develop institutional guideline for antibiotic prophylaxis in this patient population. The objective was to characterize the prophylactic antibiotic usag...
When doctors call, it is usually because the patient has multiple drug allergies and/or drug interactions that make antibiotic selection difficult. Based on Infectious Disease Society of America/American Thoracic Society guidelines, I have organized the information in a chart that makes sense to me....
Are we ready for a world without antibiotics? The answer is clearly no! Today, antibiotics are critical to treat bacterial infections. Indeed, there are very few therapeutic compounds, if any, able to modulate the inflammatory burst during severe sepsis [42]. Anti-toxin therapy could represent ...
The most common antibiotic regimen was a single cefazolin dose, with the next most common regimen included scheduled ceftriaxone and metronidazole. Overall, there were no documented central nervous system or skin and soft tissue infections during the initial admission, while 4 patients (12%) were ...
For P. berghei infections, 8–12-week-old TO female mice were intraperitoneally injected with 100 μl EF1 P. berghei-infected blood. Two days later, a group of four to five mice with 3–8% parasitemia was anaesthetised by 4 μl g−1 intramuscular injection of Rompun (0.33%)...
Recurrent urinary tract infection (rUTI) in adult women is one of the most common infections in humans. Bacteria from the vagina or faecal matter inoculate the periurethral area, then the bladder, causing symptoms of cystitis. The lifetime risk of a urinary tract infection (UTI) is around 40...
Beta-lactams are the most commonly used antibiotic class in critical care worldwide, accounting for instance for 69% of antibiotics consumed in France in 2015 [3]. The severity of infections and the frequent resistance in ICU-acquired infections, as well as the numerous pathophysiological ...
Ready for a world without antibiotics? The Pensières Antibiotic Resistance Call to Action Jean Carlet, Vincent Jarlier, Stephan Harbarth, Andreas Voss, Herman Goossens, Didier Pittet & the Participants of the 3rd World Healthcare-Associated Infections Forum Antimicrobial Resistance and Infect...