Conversely, Actinobacteria and Oxyphotobacteria accounted for the the compositional differences in the microbiota of 3-week antibiotic-treated mice (Fig. 5A). Furthermore, intricate dependencies exist among gut microbiota. Specifically, Serratia, Enterobacter, and Citrobacter form a positive regulatory ...
Gram-negative bacteria are protected by an additional outer membrane, rendering proteins on the cell surface attractive drug targets4,5. The natural compound darobactin targets the bacterial insertase BamA6—the central unit of the essential BAM complex, which facilitates the folding and insertion of...
The compound proved to be a potent, broad-spectrum antibiotic with activity comparable to penicillin G and erythromycin. Both gram-positive and gram-negative bacteria were susceptible to lemonomycin in vitro. The authors further note that lemonomycin, administered either orally or subcutaneously, ...
Nascimento AMA, Cursino L, Goncalves-Dornelas H, Reis A, Charton- Souza E, Marini MA (2003) Antibiotic-resistant gram-negative bacteria in birds from the Brazilian Atlantic forest. Condor 105:358-361NASCIMENTO, A.M.; CURSINO, L.; GONCALVES-DORNELAS, H.; REIS, A.; CHARTONE-SOUZA, E.;...
This overuse raises concerns about antibiotic side effects and the emergence of antibiotic-resistant bacteria. Shorter-duration antibiotic therapy has been recommended as an effective approach for most patients, reducing antimicrobial resistance, medical costs, and adverse effects4,5,6. Although official ...
(SK3310HP, KUDOS) at 53 kHz, 180 W and 30 °C for 20 min. (Step 4) to disrupt cell membranes and release cellular contents, such as hemoglobin from the red blood cell (RBC)—so called sonoporation36,37—more thoroughly, while avoiding bacteria inactivation38,39,40. After the resultant...
Patients affected by these resistant bacteria face poorer clinical outcomes and an elevated risk of death [1]. Moreover, they consume a dis- proportionate share of healthcare resources compared to patients battling non-resistant strains of the same bacteria. Beyond the immediate health implications,...
Prevalence, codetection and seasonal distribution of upper airway viruses and bacteria in children with acute respiratory illnesses with cough as a symptom. Clin Microbiol Infect. 2016;22(6):527–34. https://doi.org/10.1016/j. cmi.2016.02.004 Epub 2016/02/27. PubMed PMID: 26916343; PubMed...
particularly those that can render commonly used and even so-called “last-resort” drugs ineffective28,29. Several plasmids and integrons are crucial in these transmission events28,29,30,31. Moreover, deciphering the transfer of ARGs between bacteria originating from both human and animal hosts is...
Surveillance of drug-resistant bacteria is essential for healthcare providers to deliver effective empirical antibiotic therapy. However, traditional molecular epidemiology does not typically occur on a timescale that could affect patient treatment and outcomes. Here, we present a method called ‘genomic ...