aureus. Infections due to S. aureus are expensive and susceptibility to antibiotics is reduced in biofilm state and several methods, including anti-biofilm agents and vaccine should be applied to treat diseases related to biofilm. For prevention and inhibition of biofilm, application of antiadhesion ...
The pathogen Staphylococcus aureus can readily develop antibiotic resistance and evade the human immune system, which is associated with reduced levels of neutrophil recruitment. Here, we present a class of antibacterial peptides with potential to act both as antibiotics and as neutrophil chemoattractant...
addition of various chemical groups to the core of the penicillin molecule to generate semisynthetic versions. A range of penicillins thus became available to treat diseases caused by different types of bacteria, includingstaphylococci,streptococci,pneumococci, gonococci, and the spirochaetes ofsyphilis...
aureus (MRSA), which is characterized by the presence of a mutation that renders it resistant to methicillin, a semisynthetic penicillin used to treat staphylococcus infections that are resistant to mold-derived penicillin. This strain of S. aureus was first isolated in the early 1960s, shortly ...
baumannii so difficult to treat is critical for improved strategies that attack the pathogen. The evolution of drug resistance in A. baumannii in large part is due to acquisition of inactivating enzymes or drug target mutations blocking antibiotic lethal action7,8. These acquired alterations, which ...
Antibiotic resistance is threatening to make gonorrhoea untreatable. Point-of-care (POC) tests that detect resistance promise individually tailored treatme... SM Fingerhuth,N Low,S Bonhoeffer,... - 《Bmc Medicine》 被引量: 5发表: 2017年 加载更多研究...
The U.S. Food and Drug Administration has approved the antibiotic Zevtera (ceftobiprole medocaril sodium for injection) for three different indications, including treatment of adults with Staphylococcus aureus bloodstream infections, adults with acute bacterial skin and skin structure infections, and adult...
Lysin CF-301 is being developed to treat Staphylococcus aureus because of its potent, specific, and rapid bacteriolytic effects. It also demonstrates activity on drug-resistant strains, has a low resistance profile, eradicates biofilms, and acts synergistically with antibiotics. CF-301 was bacterio...
1. Methicillin-resistant Staphylococcus aureus (MRSA)Current/Emerging Resistant Bacteria Infection Types Resistance Notes Methicillin-resistant Staphylococcus aureus“staph” (MRSA) Infections can range from skin and soft tissue infections (cellulitis, abscess), to urinary tract infections, osteomyelitis (bone...
To assess the potential of MCPs to treat bacterial infections in vivo, RO7075573 was tested in two mouse models of infection induced by the MDR and CRAB strain ACC00535. Treatment with RO7075573 at subcutaneous (s.c.) doses of between 0.1 and 0.3 mg per kg given at 1 h and 5...