jejuni isolates with a mutation in gyrA outcompete clonally related fluoroquinolone-sensitive C. jejuni in the absence of antibiotic selection pressure in vivo (in the chicken). This indicates that the single point mutation not only confers a high-level resistance to fluoroquinolones but also ...
When he was there, he realized that he had forgotten to place a petri dish in an incubator. As a result, an unusual mold was growing there. What’s more, the staph cells that he’d been studying and were clustered around it had actually died. Fleming called the mold “penicillin”, ...
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To verify that the higher concentration of target DNA could be detected with R alone, we repeated the experiment using a 10-fold increase in the concentration of target DNA used in Fig. 2. As a result, we could see that the fluorescence signal increased over time in the presence of R al...
The analytic process begins early when using grounded theory. It starts with purposive sampling of participants to maximize range of experience, noting trends during interviews, familiarizing oneself with the data via transcripts, working with a team that possesses methods and content expertise to gener...
Extracellular pH has been assumed to play little if any role in how bacteria respond to antibiotics and antibiotic resistance development. Here, we show that the intracellular pH of Escherichia coli equilibrates to the environmental pH following treatmen
However, a disturbing trend has also been noted in that, within a very short period of time following the introduction of a new antibiotic, resistance to that antibiotic begins to emerge, a factor that is becoming increasingly meaningful as the discovery of new antibiotics wanes (1-3). There...
Resistant mutants are selected exclusively within a concentration range (mutant selection window) that extends from the point where growth inhibition begins, approximated by the minimal inhibitory concentration, up to the MPC. The dimensions of the mutant selection window can be reduced in a variety ...
, we did not detect any mobile colistin resistance genes. Transposases constituted the most common MGE class in all samples (Fig.3). The higher abundance of ARGs and MGEs including conjugative plasmids and transposons in the infant gut (Figs.1c, d and3a, b) indicates that there is a...
once a day for three successive days. The percent increase in life span (i.e., ILS) was measured by comparing the average number of days of survival of each treated group with that of a control group to which the BN-183B substance was not administered. The results are shown in Table ...