The swab should be dipped into the inoculum only before the swabbing starts, not between each rotation. 3. Once the lawn of bacteria has been created, the antibiotic discs can be applied to the plate. These sho
The growing problem of antibiotic-resistant bacteria is a major threat to human health. Paradoxically, new antibiotic discovery is declining, with most of the recently approved antibiotics corresponding to new uses for old antibiotics or structurally sim
Yes, several antibiotics are safe during pregnancy, but the choice of medication depends on the trimester and other factors. Always inform your healthcare provider if you're pregnant or planning to become pregnant. Alyse Thompson, M.D., is a freelance medical writer who has experience caring fo...
Liao:We are trying to build an entirely new pipeline for antibiotic development. The pipeline starts with a chemical screen to find a compound that can stop the activity of essential proteins in bacteria. Once we have that, we use cryo-EM to obtain the high-resolution structure of the target...
The biofilm formation process starts with the initial adhesion of free-floating cells onto solid surfaces, which is pivotal in the development of biofilms. After the attachment, the cell starts to aggregate and propagate to form microcolonies. In the initial stages of microcolony development, the ...
Actinomycin D was found to have antitumor activities, but no useable antibacterial potency. It is commonly used in anticancer therapies against a limited range of relatively rare tumor types, including choriocarcinoma of the placenta, Wilm's tumor, and Ewing's sarcoma [41]. Its main side effects...
The stepped wedge phase starts with a passive phase of 2 months in which no intervention takes place and the care is as usual. Subsequently, the intervention will start in the first hospital. The plan is to introduce the intervention following a standardized onboarding procedure in the first 2...
Finally, we used a D-loop formation assay to directly correlate the pH dependency of RecA-DNA binding with its ability to search for the homology within the donor dsDNA plasmid. Indeed, reactions at lower pH resulted in maximal activity, indicating that less RecA is required for the ...
The shortage starts, as is often the case, with pediatric forms [4]; given the resurgence of respiratory infections following the end of the hygiene measures occasioned by the COVID pandemic, scantiness was to be expected [5], and it resulted not prescription rationalization, but rather, on ...
Torsades de pointes, a life-threatening condition causing a rapid heart rate that starts in the ventricles Low blood glucose level (hypoglycemia) Excessive acidity in the body fluids (metabolic acidosis) Idiopathic thrombocytopenic purpura, a condition that causes easy bleeding and bruising because of ...