The misuse and overtreatment of antibiotics in hospitalized patients with community-acquired pneumonia (CAP) can cause multi-drug resistance and worsen clinical outcomes. We aimed to analyze the trends and appropriateness of antibiotic changes in hospita
Starting with a curated reference database of genes and SNPs/alleles that confer resistance in historical and contemporary isolates; it is possible to model a framework that predicts the antibiotic resistance profile of an isolate, and project the transition towards resistance over time. Although ...
In order to gain insight into these different bacterial responses and the relationship between them, it is useful to turn to a simple mathematical description, starting with uniform populations. View article Related terms: Agar Agar Plate Inoculum Minimum Inhibitory Concentration Antibacterial Activity Esc...
If erythromycin or tetracycline must be given with penicillin, consider starting penicillin therapy 2-3 hours earlier. Penicillin may affect platelet aggregation, significantly so in patients taking anticoagulants or thrombolytics, and may reduce estrogen levels in those taking oral contraceptives. A...
In this communication, we describe the organometallic hybrid antibiotic 2c, in which the drug metronidazole is connected to a gold(I) N-heterocyclic carbene warhead that inhibits bacterial thioredoxin reductase (TrxR). Metronidazole can be used for the treatment with the obligatory anaerobic pathogen ...
Mice performed 4 acquisition trials per day starting from four different cardinal points (South, North, East, West; maximal swimming time 120 s; 30 s on platform; inter-trial interval 60 min) during 4 consecutive days. Visual cues were present on the four walls surrounding the pool at a ...
Marinoquinoline A (28) is a pyrroloquinoline, which was isolated from Ohtaekwangia kribbensis, alongside marinoquinolines B–F, as well as from marine bacterium Rapidithrix thailandica [60]. Marinoquinolines A–C, have all been synthesised in a route comprising six linear steps, s...
On the import side, there was a significant surge in antibiotic medicines imports in 2007 and 2017, with a steady increase in antibiotic ingredient imports starting in 2016, culminating in a sharp spike in 2019. This trend can be explained by various favorable policies, including improved import...
The direct combination of experimental and ML techniques in a closed-loop approach has also benefited the development of new AMPs. Starting from a template with known antimicrobial activity and a series of homologous sequences, it was possible to train a generalized linear model to create new AMPs...
Evaluating the quality of antibiotic prescribing patterns using PPS is a starting point for fur- ther improvements within ASPs. The implementation of these PPS aligns seamlessly with national strategies, exemplified by the Lao People's Democratic Republic (PDR) National Action Plan for Elias et al....