This study, therefore, outlines an overview of the discovery and development of commonly used antibiotics; the timeline of resistance development; transmission routes of antimicrobial resistance in the agro〆cosystem; detection methods of environmental antimicrobial resistance determinants; factors involved in...
Antimicrobial, and particularly antibiotic resistance are one of the world’s biggest challenges today, and urgent action is needed to reinvigorate the antibiotic development pipeline. To inform policy discussions during and after the 2023 Swedish Presidency of the Council of the European Union, we cri...
Fig. 1: Clinical timeline and resistance phenotyping. ATimeline of patient sampling, showing samples that tested positive or negative forP. aeruginosacolonisation by culturing. Sampling points from which isolates were collected are highlighted with a green ring. The patient was treated with amoxicillin ...
Prevalence of antimicrobial resistance and its clinical implications in Ethiopia: a systematic review. Antimicrob Resist Infect Control. 2021;10(1):168. doi:10.1186/s13756-021-00965-0PubMedGoogle ScholarCrossref 76. Holloway KA, Kotwani A, Batmanabane G, Puri M, Tisocki ...
Understanding these mechanisms is crucial in the fight against antimicrobial resistance. While high doses of antibiotics can overwhelm bacteria, not all bacteria in an infection are exposed equally due to varying tissue uptake and natural resistance levels. This uneven exposure can allow some bacteria ...
Historically, antibiotic discovery has been crucial in outpacing resistance and success is closely related to systematic procedures—platforms—that have catalyzed the antibiotic golden age, namely the Waksman platform, followed by the platforms of semi-synthesis and fully synthetic antibiotics. Said ...
Despite the need to combat antibiotic resistance, the discovery of new antibacterial drugs has waned in recent years. Between the introduction of quinolone-based drugs, such as nalidixic acid in the early 1960s, and the introduction of oxazolidinones in the year 2000, there was a dramatic innova...
Timeline: The prospect for bacteriophage therapy in Western medicine Bacteriophage (phage) have been used for clinical applications since their initial discovery at the beginning of the twentieth century. However, they have ... C Mrr - 《Nature Reviews Drug Discovery》 被引量: 559发表: 2003年 Th...
In addition, although efforts to fight bacteria by targeting them with bacteriophages were largely abandoned with the discovery of penicillin and broad-spectrum antibiotics in the 1940s, the growing presence of resistance has renewed interest in these methods. In addition, a significant amount of ...
Timeline showing the discovery of antibiotics and the rise of antibiotic resistance over the course of eight decades. XDR – Extensive-drug resistant, PDR – Pan-drug resistant Full size image Fig. 4 Mechanisms of antimicrobial resistance in bacteria cells ...