As there is a very wide range of available antibiotics numbers of agents tested can be limited by picking individual representatives of antibiotic classes. For example, methicillin susceptibility is used as a guide for susceptibility to the other members of the group (i.e. flucloxacillin and oxacil...
Bacterial infections associated with multidrug resistance are among the leading causes of death and represent a major threat to the human health of the new millennium. Several pathogenic bacteria have become resistant to several antibiotic classes, and strains resistant to all available antibiotics ...
Retrospective antibiotic examples confirmed these trends and these discoveries were then applied to expand the spectrum of activity of a gram-positive-only antibiotic, fusidic acid, into a version that demonstrates a dramatic improvement in antibacterial activity against P. aeruginosa. We anticipate that...
The fact that the same drug classes are used in humans and animals and the sheer amounts of drugs administered to livestock, fuels discussions on the contribution to AMR from use of antimicrobials in agriculture in general, and in livestock in particular. Models predict that use in agriculture ...
By the early 1970s, 11 distinct antibiotic classes and more than 270 antibiotics had been brought into clinical use [99]. The process of novel antimicrobial discovery has slowed to a virtual standstill. Most antimicrobials introduced since the early 1970s have been chemical modifications of ...
& Bush, K. Hydrolysis and inhibition profiles of β-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem. Antimicrob. Agents Chemother. 54, 565–569 (2010). Article CAS PubMed Google Scholar Tzouvelekis, L. S., Markogiannakis, A., Psichogiou, M., Tass...
Upon administration into a subject, these prodrugs produce two general classes of drugs. The first class of drugs is of the general formula where R7 is —(CH2)a—(CHOH)b—(CH2)c—OH, where a is 1-4; b is 0 or 1; c is 1-5; n is 0 or 1; each of R2 and R3 is, indepen...
The ribosome is a major target for clinically used antibiotics, but multidrug resistant pathogenic bacteria are making our current arsenal of antimicrobials obsolete. Here we present cryo-electron-microscopy structures of 17 distinct compounds from six different antibiotic classes bound to the bacterial ri...
By the early 1970s, 11 distinct antibiotic classes and more than 270 antibiotics had been brought into clinical use [99]. The process of novel antimicrobial discovery has slowed to a virtual standstill. Most antimicrobials introduced since the early 1970s have been chemical modifications of ...
Levofloxacin (Levaquin - a discontinued brand) is a prescription drug used to treat bacterial sinus infections, skin infections, lung infections, ear infections, urinary tract infections, as well as infections of the bones and joints. The most frequently