Antibiotic Resistance Antibiotics were introduced as therapeutic agents against bacterial disease starting in 1943 - Major classes of antibilactam ring
Manure from each farm contained genes capable of conferring resistance to all major classes of antibiotics, including drugs that were not in use at that particular site, the authors report. The study detected 149 unique antibiotic resistance genes-some expressed at levels ranging from 192 to 28,...
1A). These ARGs, represent almost all major classes of antibiotics commonly administered to humans and animals. Fig. 1: Diversity and abundance of soil ARGs and bacterial community members. (A) Boxplots represent the number of ARGs detected in spring, summer, autumn and winter; (B) Relative...
However, rapidly increasing resistance towards the third and fourth generation antibiotics is worrisome (Livermore, 1995). Moreover, rapid emergence of resistance demands the development of newer classes of antibiotics and disturbs the global economy as well. Thus, the management of this rapidly ...
Isolation and identification of anti-tumor-promoting principles from the fresh-water cyanobacterium Phormidium tenue. Bioassay-directed fractionation of the extract of the cyanobacterium P. tenue led to the isolation of the three classes of glycolipids, viz., monogalactosy... H Shirahashi,N Murakami...
Sulfonamide antibiotics are widely used human and veterinary medicine. After their application, they are excreted in unchanged as well as in metabolized form. Due to incomplete elimination in wastewater treatment plants, they can be emitted into surface water. The environmental fate of both parent com...
Resistant to ≥3 classes of antimicrobials 36.7 37.4 37.1 0.88 1 Chi-squared P-value. Several unique multidrug resistance (MDR) profiles (n = 107) were exhibited by the E. coli isolates—78 and 68 profiles from large- and small-scale production systems, respectively. Thirty-nine profiles were...
Diphtheria—a relatively easily-preventable infection—is evolving to become resistant to a number of classes of antibiotics and in future could lead to vaccine escape, warn an international team of researchers from the UK and India.
New DNA binding compound could pave way for novel antibiotics Prior to this discovery, most cancer drugs have targeted binding to the major groove in DNA leading to the successful introduction of several new classes of anticancer drugs, including topoisomerase inhibitors such as camptothecins and anth...
Background: Methicillin-resistant Staphylococcus aureus (MRSA) is still one of the most feared hospital and, recently, community-acquired pathogens. Continuously challenged by therapies with diverse classes of antibiotics, this species has become less susceptible by elaborating different strategies. PZ-601...