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Rate or frequency-dependence is a characteristic property of antiarrhythmic drugs belonging to the Vaughan William classes I and III. The rate-dependence of class I drugs (i.e., increasing blockade of fast Na + -channels with faster rates) results from periodical drug binding to Na + -channel...
Classes of antiarrhythmic drugs [1][2] ClassDrug group Mechanism of action Examples Use Adverse effects Class I antiarrhythmics Class IA antiarrhythmics Fast sodium channel blockers Reduce or even block conduction (negative dromotropy), particularly in depolarized tissue (e.g., during tachycardia...
Class V drugs are agents whose mechanism of action is either unknown, or cannot be easily classified into one of the four Vaughan Williams classes; examples includedigoxin,adenosineand ranolazine. [Barton AK, et al.Prescriber. 2020;4b-5a] Digoxin can be used for rate control in AF, adenosine...
Many different classes of antiarrhythmic drugs have been used for rhythm control, with inconsistent results and adverse effects on mortality and morbidity. Of the available antiarrhythmic drugs, amiodarone is the single most effective drug in the prevention of atrial fibrillation recurrences and ...
The earliest schemes classified drugs into classes based on shared efficacies and toxicities. Someantiarrhythmic drugsshare important electrophysiological properties, notably block of sodium channels or of the potassium current IKr, and these can provide the basis for predicting shared or class actions and...
aAlas,my lunar calendar birthday and my solar calendar birthday are occupied by classes.Mom sent a message to me at morning,yes,she always remembers my birthday while I always forget hers.Much to my regret,mom... 呀,我的阴历生日和我的太阳历生日由类占领。当我总忘记她的时,妈妈寄发了一则...
What are the primary and secondary antiarrhythmic mechanisms for each of the following classes of antiarrhythmic drugs? Class I Class II Class III Class IV How do Class IA, IB, and IC drugs differ in their direct and indirect effects on non-nodal action potentials? click here How do Class ...
Some drugs have active metabolites that exert effects different from the parent compound. Not all drugs in the same class have identical effects, while some drugs in different classes have similar actions. 展开 DOI: 10.1161/01.cir.72.5.949 年份: 1985 ...
Antiarrhythmic drugs comprise many drug classes and have several mechanisms of action. Some classes and even some specific drugs within a class are effective with only certain types of arrhythmias. Therefore, attempts have been made to classify the different antiarrhythmic drugs by mechanism. Although ...