Antiangiogenic therapy: impact on invasion, disease progression, and metastasis.LeukemiaSTI571drug resistanceneferineP-gp proteinAntiangiogenic drugs targeting the VEGF pathway have slowed metastatic disease progression in some patients, leading to progression-free survival (PFS) and overall survival benefits...
Medical Wikipedia Related to antiangiogenic:Antiangiogenic Therapy an·ti·an·gi·o·gen·ic (ăn′tē-ăn′jē-ō-jĕn′ĭk, ăn′tī-) adj. Of or relating to a naturally occurring substance, drug, or other compound that can destroy or interfere with the fine network of blood ves...
Angiogensis plays an important role in tumor growth and metastasis, and anti-angiogenic therapy is a promising treatment of cancer. 肿瘤新生血管生成在肿瘤的生长和转移过程中起着重要作用,抗血管生成治疗可能成为肿瘤治疗的新方法。 www.dictall.com 5. VEGF-A splicing: the key to anti-angiogenic therap...
Tumor endothelial cellsAnti-angiogenic therapyIn recent years, anti-angiogenic therapy has attracted considerable interest as a new class of anti-cancer medicine because it is more efficacious with a lower toxicity in comparison to traditional cyto-toxic anti-cancer drugs. the enhanced permeability and...
The first idea for developing anti-angiogenic drugs was conceived over 25years ago, mainly for cancer therapies. Despite this initial hesitations and disappointments, anti-angiogenic therapy has evolved, and is now slowly starting to be applied for treating several other pathophysiological conditions ass...
Perhaps using other drugs such as methotrexate, UFT, or capecitabine for longer term metronomic chemotherapy regimens may avoid this possibility. For example, daily low-dose oral UFT for 2 years has been used as an adjuvant therapy in non small cell lung cancer.57 In addition, the very low ...
Antiangiogenic therapy for solid tumors clearly destroys tumor vasculature and reduces tumor growth. As an unexpected bonus, drugs that neutralize VEGF signaling generate a "normalization window" for tumor vasculature. This occurs via the recruitment of pericytes to the tumor vasculature, an effect asso...
Human Gene Therapy. 20, 103–111 (2009). Google Scholar Ning, T. et al. Low-dose Endostatin normalizes the structure and function of tumor vasculature and improves the delivery and anti-tumor efficacy of cytotoxic drugs in a lung cancer xenograft murine model. Thoracic Cancer. 3, 229–...
1. Antiangiogenic Therapy a Two-Trick Pony? [J] . Tracy Hampton JAMA: the Journal of the American Medical Association . 2005,第9期 机译:抗血管生成疗法是两招小马? 2. Hemorrhage caused by antiangiogenic therapy within previously irradiated areas: expected consequence of tumor shrinkage or a ...
First, adaptive resistance to anti-angiogenic treatment is an indirect method of resistance adopted by malignant cells to cope with blood supply shortage caused by anti-angiogenic therapy. This type of resistance is considered functional compensation of the target inhibited by anti-angiogenic therapy uti...