Anti -angiogenic agents deprive tumors of oxygen and nutrients and inhibit their survival and continued growth. Examples of anti-angiogenic drugs include bevacizumab ( Avastin ), a recombinant humanized monoclonal antibody directed against the vascular endothelial growth factor ( VEGF ) and targeted ...
Boehm S, Rothermundt C, Hess D, Joerger M. Antiangio� genic drugs in oncology: a focus on drug safety and the elderly - a mini-review. Gerontology 2010; 56: 303-309Boehm S, Rothermundt C, Hess D, Joerger M. (2010) Antiangiogenic drugs in oncology: A focus on drug safety and...
It also relates to the use of peptide analogs or a combination of peptides referred to as MuJ-7 as anticancer drugs in restricting the tumor growth and spread by inhibiting tumor angiogenesis. MuJ-7, in addition inhibits metastasis through its antiangiogenic activity in all cancers. The ...
It also relates to the use of peptide analogs or a combination of peptides referred to as MuJ-7 as anticancer drugs in restricting the tumor growth and spread by inhibiting tumor angiogenesis. MuJ-7, in addition inhibits metastasis through its antiangiogenic activity in all cancers. The ...
In complement to the direct antitumor effects of radiation therapy and anti-EGFR drugs, a strong antiangiogenic effect may be obtained with therapeutic ... Bozec,A. - 《Molecular Cancer Therapeutics》 被引量: 55发表: 2005年 The cardioprotective effects of statins inhibition of complement injury, ...
It has been hypothesized that anti-angiogenic drugs enhance efficacy of cytotoxic drugs by "normalizing" abnormal tumor vessels and improving drug penetration. Nevertheless, the clinical relevance of this phenomenon is still unclear with several studies over recent years suggesting an opposing relationship...
Results Among 1 521 231 patients who experienced adverse drug reactions after receiving anticancer drugs, 217 664 cases were potentially associated with the receipt of antiangiogenic drugs. Of those, 494 patients (median age, 67 years [interquartile range, 59-73 years]; 253 women [51.2%...
Inhibition of tumor angiogenesis is a universal approach for the treatment of tumors. This calls for the development of more effective next-generation anti-angiogenic drugs for advancing the treatment of intractable cancers. Credit: Wikimedia Commons ...
chemotherapy," explains Dr. Kerbel. "Further, our findings provide a potential explanation of why not all chemotherapy drugs will necessarily have their efficacy enhanced by the addition of an antiangiogenic agent when the mechanism involves blunting CEP mobilization acutely induced by the chemotherapy...
New anti-angiogenic drugs like tyrosine kinase inhibitors generated optimistic results in phase II trials, but failed to translate into positive results in phase III trials. In this overview some critical aspects of the biology of tumor angiogenesis and potential pitfalls...关键词: Angiogenesis Anti-...