抗TNF-α疗法肿瘤坏死因子病原体巨噬细胞炎性细胞因子肿瘤坏死因子(TNF)是各种病原体及其相关物质(内毒素,免疫复合物等)等刺激引起的以单核细胞,巨噬细胞等为主产生的炎性细胞因子.已知有α,β两种,因可抑制肿瘤细胞的增殖和伤害作用而得名.其他的生物学作用有:刺激淋巴细胞,中性粒细胞的作用;由刺激破骨细胞引...
Disease-modifying medications should be started as soon as the diagnosis of RA has been made. Therapeutic options range from nonsteroidal anti-inflammatory drugs that are not disease-modifying, to steroids that are mildly disease-modifying, to disease-modifying antirheumatic agents (DMARDs) that are ...
Clinical Professor, University of Texas Southwestern Medical Center at Dallas The primary reason for initiating biologic therapy in RA is the presence of continued disease activity despite treatment with conventional therapy. Although biologics can be used as initial disease-modifying therapy, their cost ...
-TNF therapy was nearly entirely funded by the Arthritis Research Campaign (ARC) in the United Kingdom. Its long-term investment in this field since 1986 has been rewarded by the benefits to its patient supporters, which will increase following the positive NICE evaluation of anti-TNF therapy....
Patients on anti-TNFα therapy had significantly fewer T-cells, greater EBV load, and increased levels of transcripts from EBV-lytic genes of all kinetic classes compared to controls. Furthermore, exposure of EBV-infected B-cell lines to anti-TNFα antibodies resulted in increased levels of BZL...
The agreement between 2D and 3D measurements was moderate (rc=0.77). Conclusions: A 3D ultrasound supported by the volume nuchal translucency software may provide reliable measurements of the fetal NB in the first trimester.Taku KobayashiToshifumi Hibi...
aWhat do you think the hardest part is 什么您认为最坚硬的部分是[translate] a120261.94 120261.94[translate] aIs not a suitable candidate for anti-TNFα therapy for the following reasons: 不是一名适当的候选人为anti-TNFα疗法为以下原因:[translate]...
Effect of anti-TNF therapy. Effect of anti-TNF therapy.Jt Bone Spine. 2009D Wendling,V Di Martino,C Prati,E Toussirot,G Herbein.Spondyloarthropathy and chronic B hepatitis: effect... D Wendling,VD Martino,C Prati,... - 《Joint Bone Spine》 被引量: 83发表: 2009年 Impaired Th1 ...
Since the late 1990s, tumor necrosis factor alpha (TNF-α) inhibitors (anti-TNFs) have revolutionized the therapy of immune-mediated inflammatory disea
apress any to continue... 正在翻译,请等待...[translate] aHas received any anti-TNFα biologic therapy other than adalimumab which is prohibited 接受了所有anti-TNFα生物疗法除被禁止的adalimumab之外[translate]