抗TNF-α疗法肿瘤坏死因子病原体巨噬细胞炎性细胞因子肿瘤坏死因子(TNF)是各种病原体及其相关物质(内毒素,免疫复合物等)等刺激引起的以单核细胞,巨噬细胞等为主产生的炎性细胞因子.已知有α,β两种,因可抑制肿瘤细胞的增殖和伤害作用而得名.其他的生物学作用有:刺激淋巴细胞,中性粒细胞的作用;由刺激破骨细胞引...
Baraliakos X, Braun J (2010) Anti-TNF-alpha therapy with infliximab in spondyloarthritides. Expert Rev Clin Immunol 6: 9-19.Baraliakos X, Braun J. Anti-TNF-alpha therapy with infliximab in spondyloarthritides. Expert Rev Clin Immunol 2010;6:9-19....
Mycobacterium porferae infection in a psoriasis patient on anti-tnf-a therapy(抗tnf-a治疗牛皮癣患者的猪分枝杆菌感染) 热度: Role of antibody therapy in lymphoid malignancies:在淋巴系统恶性肿瘤的抗体治疗中的作用 热度: R REVIEW Anti-TNFAntibodyTherapyinRheumatoidArthritisandtheRiskofSeriousInfectionsandMali...
Several biosimilar drugs based on the anti-TNF agents adalimumab, infliximab, and etanercept are now available for use in patients with psoriasis. The favorable cost differential of biosimilars is expected to improve access to biologic therapy for biologic-naive psoriasis patients, who are often under...
adding an anti-TNF medication should be considered in order to optimize the response and avoid further joint damage. Noticeable improvement should be seen with this combination treatment over a 3- to 6-month time period. The important message is to treat, assess, and change therapy if needed,...
In humans, the role of anti-tumour necrosis factor (TNF)-α therapy in severe sepsis and septic shock is debatable. The aim of this meta-analysis was to determine the efficacy of anti-TNF-α therapies against placebo in patients with severe sepsis or septic shock.INTERNATIONAL JOURNAL OF CLIN...
Approximately 30% of IBD patients do not respond to anti-TNF therapy (primary non-responders), and nearly half of those who initially benefit from these drugs experience a loss of clin- ical benefits within the first year, necessitating dose esca- lation or treatment alteration, referred to as...
When should treatment with tumor necrosis factor (TNF) blockers in a patient with rheumatoid arthritis (RA) be initiated? Dr. Samar Response From the Expert Stanley B. Cohen, MD Clinical Professor, University of Texas Southwestern Medical Center at Dallas The primary reason for initiating biologi...
-TNF therapy was nearly entirely funded by the Arthritis Research Campaign (ARC) in the United Kingdom. Its long-term investment in this field since 1986 has been rewarded by the benefits to its patient supporters, which will increase following the positive NICE evaluation of anti-TNF therapy....
All the patients previously received immunosuppressive drugs, including methotrexate (nine) and leflunomide (four). Three patients had a brain MRI before initiation of anti-TNF treatment, which was normal. Clinical episode was stroke-like in three cases, clinically isolated syndrome (CIS) in five ...