Concern has been raised about an increased risk of lymphoma and skin cancers in patients with rheumatoid arthritis due to administration of anti-TNF-alpha drugs. Meta-analysis of observational data from registries as well as from randomized controlled trials has failed to show a significant increase...
Biologic therapy involving anti-tumor necrosis factor-α (anti-TNFα) agents has fundamentally changed the management of patients with immune-media
Trotta F, Valentini G. Safety of anti-TNFα biological drugs. Reumatismo 2005; 57 (Suppl. 1):34-39.Trotta F,Valentini G.Safety of anti-TNFalpha biological drugs. Reumatizam . 2005Trotta, F., and Valentini, G. (2005). Safety of anti-TNFalpha biological drugs. Reumatismo 57, 34-39. ...
Anti-TNF-α drugs for refractory inflammatory bowel disease: Clinical- and cost-effectiveness analyses. Ottawa: Canadian Agency for Drugs and Technologies in Health;; 2009.Anti-TNF-α drugs for refractory inflammatory bowel disease: Clinical- and cost-effectiveness analyses. Asassi N,Black...
Anti TNF drugs are established therapy in rheumatoid arthritis with some restrictions according national recommendations. Stopping therapy for short periods does not necessarily lead to flares. Recently, it has been demonstrated that combination therapy with methotrexate and infliximab can be tapered and di...
patients had an average of 23 swollen and 24 tender joints and had had rheumatoid arthritis for an average of 12 years. Their average DAS28 score was 6.9, and they had had an average of 1.5 anti-TNF-alpha therapies before the study. Their average methotrexate dose was 16.5 mg per week....
Anti-TNFMultiple sclerosisPharmacovigilanceIntroduction Anti-TNF alpha treatments are increasingly prescribed in various rheumatological or gastroenterological inflammatory diseases. Several adverse events, including neurological episodes have been reported in the literature. Relation to treatment is a major concern...
Paradoxical psoriasiform reactions to anti-tumor necrosis factor α (TNFα) agents have been described. We aimed to study the association between these reactions and polymorphisms in genes previously associated with psoriasis or other autoimmune diseases. A total of 161 patients with plaque-type psoria...
The discovery of the major role of TNF alpha in the physiopathology of certain inflammatory diseases and notably in rheumatoid arthritis and Crohn's disease has led to the development of anti-TNF alpha drugs. These new therapeutic arms issued from bio-technology have rapidly demonstrated their effi...
CONTEXT: The risk of bacterial infection is increased in patients treated with drugs that inhibit tumor necrosis factor alpha (TNF-alpha). Little is known ... A Strangfeld,J Listing,P Herzer,... - 《Jama》 被引量: 991发表: 2009年 Anti-TNF(alpha) therapy in rheumatoid arthritis: an upda...