Anti-HMGB1 neutralizing antibody ameliorates gut barrier dysfunction and improves survival after hemorrhagic shock. Mol Med. 2006;12:105–14.Yang R, Harada T, Mollen KP, Prince JM, Levy RM, Englert JA, Galloitsch-Peerta M, Yang L, Yang H, Tracey KJ, Harbrecht BG, Billiar TR, Fink MP...
Recently, we found that the translocation and release of HMGB1 from neuronal nuclei to the extracellular space occurs both in ischemic and traumatic brain injuries, and that a neutralizing monoclonal antibody (mAb) against HMGB1 significantly ameliorates the resultant brain injuries by protecting against...
Intravenous injection of neutralizing anti-HMGB1 mAb has potential as a novel therapeutic strategy for ICH.doi:10.1038/srep46243Wang, DengliLiu, KeyueWake, HidenoriTeshigawara, KiyoshiMori, ShujiNishibori, MasahiroNature Publishing GroupScientific Reports...
Anti-HMGB1 neutralizing antibody ameliorates gut barrier dysfunction and improves sur- vival after hemorrhagic shock. Mol Med. 2006;12:105-114.Yang R, Harada T, Mollen KP, et al: Anti-HMGB1 neutralizing antibody ameliorates gut barrier dysfunction and improves survival after hemorrhagic shock. Mol ...
(Figures 4a2andb2), we conclude that a combination of released HMGB1 and nucleotides like ATP is responsible for the activation of DCs. To confirm the impact of HMGB1 on activation of DCs, SNs of the treated tumor cells were supplemented with a neutralizing antibody against HMGB1 and added ...
Although Ag-specific antibodies were detected in all vaccinated animals, a greater neutralizing Ab response was associated with the HMGB1 adjuvant. Furthermore, these responses improved CD8 T+-cell effector and memory responses and provided protection against a lethal mucosal influenza A/PR/8/34 ...