Histone H3-H4 chaperone anti-silencing function 1 (ASF1) plays an important role in the polymerization, transport, and modification of histones. However, the significance of ASF1B in lung adenocarcinoma (LUAD) is largely overlooked. We investigated the aberrant expression of ASF1B in LUAD and...
Glioblastoma is characterized by high aggressiveness, frequent recurrence, and poor prognosis. Histone acetylation-associated genes have been implicated in its occurrence and development, yet their predictive ability in glioblastoma prognosis remains unc
clinical significance of the most common chromosome translocations in adult acute myeloid leukemia. j natl cancer inst monogr. 2008, 39: 52-57. pubmed google scholar ohnishi k: pml-raralpha inhibitors (atra, tamibaroten, arsenic troxide) for acute promyelocytic leukemia. int j clin oncol. ...
Full size image To determine which isomer causes the +105.0215 Da mass shift, we first determined whether the pan anti- Kbzantibody recognises the above three isomers. We designed and synthesised four peptides based on the histone H4 amino acid sequence containing the lysine with a + 1...
Histone H3/H4 acetylation, p21 expression, and caspase-3 activation can be induced by MS-275 in bone marrow mononuclear cells. Even though MS-275 effectively inhibits HDAC in vivo in patients with advanced myeloid leukemias, responses by classical criteria were not seen [92]. Pre-clinical ...
In children with SLE anti-nucleosome reactivity is present; it is in part due to anti-dsDNA antibodies and in part to antibodies recognizing conformational epitopes that may be related to the H3H4-DNA nucleosome subparticle. Its clinical significance for diagnosis is not greater than that of the...