Membranous nephropathy and cerebellar degeneration with anti-GAD antibodies in type 2 diabetes mellitusMembranous nephropathyCerebellar degenerationAnti-glutamic acid decarboxylase (GAD) autoantibodiesType 2 diabetes mellitusAims To study the potential pathogenic significance of the coexistence of membranous ...
His blood sugar level gradually increased to 1994, and therefore he was admitted to our hospital and insulin therapy was started in 1997. During the admission period, he was found to have anti-GAD and JA-2 antibodies indicating that he was suffered from type 1 diabetes. We report this case...
Latent Autoimmune Diabetes Mellitus in Adults (LADA): the Role of Antibodies to Glutamic Acid Decarboxylase in Diagnosis and Prediction of Insulin Dependency Type 1 diabetes mellitus in adults may present in a manner similar to that of Type 2 diabetes but with a late development of insulin depende...
Antibodies to glutamic acid decarboxylase and insulin-dependent diabetes in patients with auto-immune polyendocrine syndrome type I J Clin Endocrinol Metab (1996) A. Saiz et al. Autoantibodies to glutamic acid decarboxylase in three patients with cerebellar ataxia, late-onset insulin-dependent diabetes...
(IDDM) and stiff-man syndrome (SMS), IDDM is an autoimmune disease that results from T cell mediated destruction of pancreatic insulin-secreting beta cells. Islet-reactive T cells and antibodies primarily to GAD65 (also named beta cell autoantigen) can be detected in peripheral blood of 80% ...
Stiff Person Syndrome (SPS) is a rare autoimmune neurological disease attributable to autoantibodies to glutamic acid decarboxylase (anti-GAD) more usually associated with the islet beta cell destruction of autoimmune type 1 diabetes (T1D). SPS is characterized by interference in neurons with the ...
For in vivo studies or highly sensitive assays, we recommend Ultra-LEAF™ purified antibody (Cat. No. 844503) with a lower endotoxin limit than standard LEAF™ purified antibodies (Endotoxin <0.01 EU/µg).This antibody demonstrates weaker reactivity to human compared to mouse GAD65/GAD2 ...
Autoantibodies to pancreatic beta cell antigens are important serological markers of type 1 diabetes mellitus. The antigens recognised by these antibodies include insulin, glutamic acid decarboxylase (GAD65 kDa isoform) and the islet cell antigen IA2 or ICA512. ASSAY PRINCIPLE In DEMEDITEC’s GADAb...
Sujesh Kumar N , K. N. Subhakumari . (2015) Role of anti-GAD, anti-IA2 antibodies and C-peptide in differentiating latent autoimmune diabetes in adults from type 2 diabetes mellitus. International Journal of Diabetes in Developing Countries Online publication date: 19-Oct-2015. /...
type 2 diabetesThe aim of the present study was to evaluate the importance of the phases of insulin secretion, measured during an intravenous glucose tolerance test (IVGTT), and anti-GAD65 antibodies as a beta-cell autoimmune marker, in the proper early diagnosis of the type of diabetes in ...