doi:WO1998017304 A1Geesin, Jeffrey C.Gosiewska, AnnaWOWO1998017304A1 1997年10月24日 1998年4月30日 Johnson & Johnson Medical Anti-fibrotic agent assayWO1998017304A1 Oct 24, 1997 Apr 30, 1998 Johnson & Johnson Medical Anti-fibrotic agent assay
The devices and methods comprise an antifibrotic agent to degrade shrink, relax or stretch at least a portion of the fibrotic tissue. In some embodiments, the methods and devices are configured to immediately release an effective amount of the antifibrotic agent within 24 hours. In some ...
Phase 2 Trial of PRM-151, an Anti-Fibrotic Agent, in Patients with Myelofibrosis: Stage 1 Results Author links open overlay panelSrdan Verstovsek MD PhD 1, Ruben A. Mesa MD 2, Lynda M Foltz MD 3, Vikas Gupta MD FRCP, FRCPath 4, John O Mascarenhas MD MS 5, Ellen K. Ritchie ...
Using the deep-DPC platform, over 100,000 images generated from 1,400 compounds were processed, identifying Neo-Przewaquinone A as a potent anti-fibrosis agent. Neo-Przewaquinone A exerts its effects by inhibiting TGF-β receptor I, thereby maintaining cells in a resting state and arresting ...
Our study provides a theoretical basis for nimodipine as a potential alternative agent for fibrosis in TED. Due to the vast cost and long period in developing new drugs, conventional drugs with novel uses are greatly cost-effective. Additionally, the potential mild anti-hypertensive and ...
oral administration of D-CeO2in chitosan/alginate hydrogel showed a significant therapeutic effect on colitis with anti-inflammatory and anti-fibrosis functions. D-CeO2could also be employed as a CT contrast agent for noninvasive gastrointestinal tract (GIT) imaging (Fig.1). D-CeO2had excellent ...
Suberoylanilide hydroxamic acid: a potential epigenetic therapeutic agent for lung fibrosis? The European respiratory journal 34, 145–155 (2009). Article CAS Google Scholar Klingberg, F., Hinz, B. & White, E. S. The myofibroblast matrix: implications for tissue repair and fibrosis. J Pathol...
These results indicate that EGCG is also a strong liver anti-fibrogenic agent for human hepatic stellate cells. Figure 3 EGCG reduced the expression of liver fibrogenic genes and the activity of the TGF-β/Smad signaling pathway in a dose-dependent manner in human hepatic stellate LX-2 cells....
Our results suggest that 6-BIO may be a potential therapeutic agent against kidney diseases, as well as for preventing kidney damage caused by UUO and TGFβ. The semisynthetic cell-permeable indirubin derivative 6-BIO belongs to bis-indole family and naturally occurs in edible gastropod mollusks ...
Kataoka S, Umemura A, Okuda K, Taketani H, Seko Y, Nishikawa T, Yamaguchi K, Moriguchi M, Kanbara Y, Arbiser JL, et al. Honokiol Acts as a Potent Anti-Fibrotic Agent in the Liver through Inhibition of TGF-β1/SMAD Signaling and Autophagy in Hepatic Stellate Cells.International Journal...