To explore the potential utility of the adhesive anti-fibrotic interfaces, we demonstrated long-term in vivo electrophysiological recording and stimulation enabled by the implantable electrodes with the adhesive interface in a rat model for 84 days (Fig.6). For continuous in vivo monitoring and modul...
These findings may offer a promising strategy for long-term anti-fibrotic implant–tissue interfaces.#A study shows that implants with an adhesive implant–tissue interface mitigate the formation of a fibrous capsule when attached to various organs in mice, rats and pigs....
et al. Suppression of the fibrotic encapsulation of silicone implants by inhibiting the mechanical activation of pro-fibrotic TGF-β. Nat. Biomed. Eng. 5, 1437–1456 (2021). Article Google Scholar Wang, Y. et al. Robust, self-adhesive, reinforced polymeric nanofilms enabling gas-permeable ...
Furthermore, P10G20 lowers down the in vivo oxidative stress and prevents IUA with less fibrotic tissue and better endometrial regeneration in the animal model. It can effectively downregulate fibrosis-related transforming growth factor beta 1 (TGF-β1) and vascular endothelial growth factor (VEGF)...
In this study, we describe the role of HDAC1/2 in promoting one of the first and crucial steps of EOC trans–coelomic metastasis (i.e. the adhesion of EOC cells to fibrotic peritoneum) and shed light on molecular mechanisms conferring MC permissiveness to EOC progression. This study demonstrat...
However, for the Saline group, the fibrotic tissue stopped the tissue shrinkage, leading to a larger diameter postmortem. Besides, there was more obstruction observed when trying to inject methylene blue solution through the Saline group compared to that of P10G20 group, showing that there was ...
AB0078 ANTI-FIBROTIC EFFECT OF DIFFERENT FUCOIDANS IN OSTEOATHRITIC FIBROBLAST-LIKE-SYNOVIOCYTES Background Synovial fibrosis is a pathological process observed in several musculoskeletal disorders that contributes to articular pain and stiffness. It i... CV García,H Domínguez,FJ Blanco,... - 《Ann...
Hagiwara Y, Ando A, Onoda Y, Takemura T, Minowa T, Hanagata N et al. Coexistence of fibrotic and chondrogenic process in the capsule of idiopathic frozen shoulders. Osteoarthritis Cartilage. 2012; 20 (3): 241-249. Singh VP, Bali A, Singh N, Jaggi AS. Advanced glycation end products and...
While chronic inflammation can lead to scarring and formation of fibrotic tissue because the time course of our injury models is less than ten days, the inflammatory markers observed are that of a normal wound healing process. The proliferation phase can begin as early as day 1, and lasts up...
anti-Integrin β1 (1:500, mouse, Abcam, ab30394), anti-N-Cadherin (1:200, rabbit, Cell Signaling, 13116), anti-YAP (1:100, rabbit, Cell Signaling, 14074), anti-RUNX2 (1:1000, rabbit, Cell Signaling, 12556), anti-Paxillin (1:200, rabbit, Abcam, ab32084), anti-Lamin A/C (...