To explore the potential utility of the adhesive anti-fibrotic interfaces, we demonstrated long-term in vivo electrophysiological recording and stimulation enabled by the implantable electrodes with the adhesive interface in a rat model for 84 days (Fig.6). For continuous in vivo monitoring and modul...
These findings may offer a promising strategy for long-term anti-fibrotic implant–tissue interfaces.#A study shows that implants with an adhesive implant–tissue interface mitigate the formation of a fibrous capsule when attached to various organs in mice, rats and pigs....
Bioadhesive devices can be used to create conformable tissue–device interfaces without suturing. However, the development of such technology faces challenges related to the need for external stimuli or long periods of time for tissue adhesion, fatigue-related breakdown of the stretchable electrodes and...
There were still no obvious cracks at the interfaces as shown in Fig. 2a, when compared with the normal adhesive hydrogels (Fig. 2b). Hence, the optical microscopy and SEM further demonstrate the good self-healing properties of the hydrogels. Download: Download high-res image (2MB) Download:...
While chronic inflammation can lead to scarring and formation of fibrotic tissue because the time course of our injury models is less than ten days, the inflammatory markers observed are that of a normal wound healing process. The proliferation phase can begin as early as day 1, and lasts up...