incollection{4090305, author = {De Paepe, Boel}, booktitle = {Topics in anti-cancer research, vol. 2}, editor = {Rahman, Atta-ur and Zaman, Khurshid}, issn = {2213-3585}, language = {eng}, publisher = {Bentham Science}, title = {Anti-angiogenic therapy for cancer: past, present...
With the role of angiogenesis in tumor growth and progression firmly established, considerable effort has been directed to antiangiogenic therapy as a new modality to treat human cancers. Antiangiogenic agents have recently received much widespread attention but strategies for their optimal use are still...
genetic and phenotypic mutations.33,34,35,36Furthermore, cancerous tumors can escape into remote normal organizations through blood and lymphatic circulation to invalidate the drugs and worsen the condition of patients.37,38,39,40As an emerging treatment, anti-angiogenic therapy fights cancer by norm...
Thus, targeting the proliferation of tumor neovasculature will form an effective anti-cancer therapy. With the identification of drug and biological molecules that inhibit the growth of tumor endothelium, several attempts have been made in preclinical and clinical research to evaluate the potential of ...
reviewgivesabriefbackgroundtobreastcancerangiogenesis,alsofocusingoncurrentprog-ressinthefieldofantiangiogenictherapyforbreastcancerandissuesregardingfuturetherapeuticdevelopment.Keywordsbreastcancer;angiogenesis;antiangiogenictherapy;vascularendothelialgrowthfactor(VEGF):bevacizumabBreastcancerisoneofthemostcommontumorsin...
Bevacizumab (Avastin), a humanized anti-VEGF monoclonal antibody for cancer therapy. Biochem. Biophys. Res. Commun. 333, 328–335 (2005). CAS PubMed Google Scholar Jain, R. K. Antiangiogenic therapy for cancer: current and emerging concepts. Oncology (Williston Park) 19, 7–16 (2005). ...
Anti-Angiogenic Therapy for the Treatment of Lung CancerHongbin Chen, MD, PhD
Much effort has been directed towards the development of drugs that disrupt or normalize this process for cancer therapy. Some tumors also contain vasculogenic mimicry channels consisting of cancer cells and their extracellular matrix. In solid tumors, vasculogenic mimicry has been found to be strongly...
International Journal of Molecular Sciences Review Resistance to Anti-Angiogenic Therapy in Cancer—Alterations to Anti-VEGF Pathway Yoshiro Itatani 1, Kenji Kawada 1,* ID , Takamasa Yamamoto 1,2 and Yoshiharu Sakai 1 1 Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto ...
Antiangiogenic therapy for glioblastoma: current status and future prospects. Clin Cancer Res. 2014;20(22):5612 - 5619.Batchelor TT, Reardon DA, de ... ER Gerstner,TT Batchelor - 《Cancer Journal》 被引量: 177发表: 2012年 Molecular targeted therapy for advanced hepatocellular carcinoma: current...