Anti-EGFR and anti-VEGF agents: important targeted therapies of colorectal liver metastases. World J Gastroenterol. 2014;20:4263-75.FENG Q Y, WEI Y, CHEN J W, et al. Anti-EGFR and anti- VEGF agents : import anttargeted therapies of colorectal liver me- tastases [ J ]_ World J ...
Introduction: The optimal Anti-VEGF (vascular endothelial growth factor) and Anti-EGFR (epithelial growth factor receptor) antibody regimen to combine with chemotherapy in the first-line treatment for metastatic colorectal cancer remains to be better defined. Results from randomized controlled trials are...
EGFR tyrosine-kinase inhibitors (EGFR-TKIs) remain a standard therapy in EGFR-mutant advanced NSCLC.8Despite the high initial objective response rate (ORR), tumors inevitably become resistant to EGFR-TKIs. The secondary EGFR mutations are considered one possible resistance mechanism. For instance, EGF...
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and details of combination therapies are omitted. ICI immune checkpoint inhibitors, mAb monoclonal antibody, BiTE bispecific T cell engager, ALL acute lymphoid leukemia, NSCLC non-small cell lung cancer, MSI-H microsatellite instability-high, dMMR deficient mismatch repair, TNBC triple-negative breast...
CRKL在多种癌症中表达升高，CRKL的扩增驱动癌转化和表皮生长因子受体(EGFR)抑制剂耐药性。这些发现表明，异常的CRKL表达在肿瘤进展中起着重要作用。该研究发现CRKL在抗PD-1耐药的HCC组织中表达上调，CRKL过表达通过募集TANs和重塑肿瘤免疫微环境(TIME)促进抗PD-1耐药，提示CRKL是克服抗PD-1耐药的潜在靶点。这些发现...
Vandetanib could inhibit tumour cell proliferation and survival by blocking EGFR and could inhibit tumour-induced neo-angiogenesis by blocking VEGF activity and has been investigated in a variety of human cancers, including NSCLC (Wedge et al, 2001; Wilhelm et al, 2004; Naumov et al, 2009; ...
(known as FLT-1) is the first identified dual-function VEGF receptor, a 180–185 kDa glycoprotein, acting as a co-receptor for VEGF-A, VEGF-B, and PlGF.100VEGFR-1 is mainly active in various endothelial cells and non-endothelial cells (monocytes,101macrophages,102hematopoietic stem cells...
小鼠血管内皮生长因子A(VEGFA)ELISA试剂盒 英文名: VEGFA ELISA Kit 小鼠血管内皮钙黏蛋白(CDH5)ELISA试剂盒 英文名: CDH5 ELISA Kit 小鼠血管紧张素Ⅱ(ANGⅡ)ELISA试剂盒 英文名: ANGⅡ ELISA Kit 小鼠血管紧张素Ⅰ(AngⅠ)ELISA试剂盒 英文名: AngⅠ ELISA Kit ...
MCE 抗血液肿瘤化合物库 Anti-Blood Cancer Compound Library.docx,抗癌化合物库系列 Anti-Cancer Series 癌症是全球第二大死亡原因,严重威胁人类健康。细胞周期调控和细胞分裂过程失调是导致癌症发生的主要原因。在癌症治疗中,常用的治疗方法包括化疗、放疗、靶向治疗、