Purpose : Patients with diabetic macular edema are commonly treated with intravitreal injections of anti-vascular endothelial growth factor (VEGF) agents. However, a substantial amount of patients show a suboptimal response to this treatment. It is therefore important to identify poor responders to ...
GDF-15 is part of the transforming growth factor (TGF)-β superfamily and functions as a regulatory cytokine for cell cycle control, development and repair processes in response to e.g. inflammatory processes35,36,37. In preclinical studies, GDF-15 had a wider distribution in the developing ...
Immune checkpoint inhibitors (ICI) have revolutionized treatment for various cancers; however, durable response is limited to only a subset of patients. Discovery of blood-based biomarkers that reflect dynamic change of the tumor microenvironment, and predict response to ICI, will markedly improve curre...
Expression of p95HER2, a truncated form of the HER2 receptor, and response to anti-HER2 therapies in breast cancer. J Natl Cancer Inst. 2007;99(8):628–38. Article CAS PubMed Google Scholar Gewinner C, Wang ZC, Richardson A, et al. Evidence that inositol polyphosphate 4-phosphatase ...
Is VEGF a predictive biomarker to anti-angiogenic therapy? Crit. Rev. Oncol./Hematol., 79: 103-111.Otrock Z, Hatoum H, Musallam K, Awada A and Shamseddine A. Is VEGF a predictive biomark- er to anti-angiogenic therapy? Crit Rev Oncol Hematol 2011; 79: 103-111....
While immune checkpoint blockade has greatly improved clinical outcomes in diseases such as melanoma, there remains a need for predictive biomarkers to determine who will likely benefit most from which therapy. To date, most biomarkers of response have b
which also has anti T790M activity, is superior to gefitinib, with a median progression-free survival of 20.6 months versus 9.7 months and a 76% response rate [48], while data on OS were not reported (NR). These results mirror those of recent Chinese phase 3 trials, including the AENEAS...
disease state or activity can be distinct in contexts of disease initiation and disease propagation. Markers of disease state may have prognostic value. By informing on disease state or activity these markers may become particularly useful for guiding treatment choice and monitoring treatment response. ...
sFRP2 supersedes VEGF as an age-related driver of angiogenesis in melanoma, affecting response to Anti-VEGF therapy in older patients. Clin Cancer Res. 2020;26(21):5709–19. https://doi.org/10.1158/1078-0432.CCR-20-0446. Article CAS PubMed PubMed Central Google Scholar Ma D, Jiang ...
Hyperreflective Walls in Foveal Cystoid Spaces as a Biomarker of Diabetic Macular Edema Refractory to Anti-VEGF TreatmentPrognostic markersRetinal diseasesHyperreflective walls in foveal cystoid spaces on sectional OCT images in DME. ( ) Hyperreflective walls (white and black arrows) in the bottom ...