field fluorescein angiography was extracted for calculating RVBA by summing the real size (mm2) of all the pixels automatically.#For the entire cohort, the global RVBA for the entire retina decreased from 67.1 ± 15.5 to 43.6 ± 18.8 mm2after anti-VEGF treatment at six months (P< 0.001)....
In the patients with recurrent EOC who experienced a compete response to therapy > 6 months, 56.0% (51/91) had thrombocytosis at diagnosis, and 92.3% (84/91) of these patients had normalized platelet levels by the end of primary therapy. In the treatment resistant cohort (n = 13...
Temporal analysis of canonical pathways for lung revealed that acute phase response signalling pathway, VEGF signaling mitochondrial dysfunction and NRF-2 mediated oxidative stress response pathway were identified for all exposure durations suggesting the protective response in defense in hypobaric hypoxia. ...
Tumor PD-L1 expression is associated with a favorable objective response to anti-PD1/ anti-PD-L1 therapy in both the preclinical models of liver cancer [71] and in clinical trials on patients with HCC [12,59,63]. As shown in Table1, higher density of infiltrating T cells, particularly CD...
However, there remains a subset of patients that do not respond despite their tumors exhibiting PD-L1 expression, which highlights the need for additional biomarkers relevant to response. Here, we review checkpoint inhibitor signal pathways, resistance and sensitivity mechanisms, as well as response ...
In the later stage of immune response, like anti-inflammatory M2 type, TAM mainly plays an immunosuppressive role, highly expressing CD206, CD204, vascular endothelial growth factor (VEGF), CD163 and arginase (Arg-1), and relying on fatty acid oxidation (FAO) [56]. The study has shown ...
TFE3 is closely related to TFEB, both of which are part of the cell response to endoplasmic reticulum. Reticular stress causes its translocation to the nucleus. In cellular homeostasis mTOR phosphorylation prevents TFE3/TFEB activation and translocation into the nucleus. Under cellular stress/...
Is VEGF a predictive biomarker to anti-angiogenic therapy? Crit. Rev. Oncol./Hematol., 79: 103-111.Otrock ZK, Hatoum HA, Musallam KM, Awada AH, Shamseddine AI. Is VEGF a predic- tive biomarker to anti-angiogenic therapy? Crit Rev Oncol Hematol 2011;79:103-11....
(VEGF), MMPs, and other molecules such as fibroblast growth factors (FGF), urokinase-type plasminogen activator, and IL-6, have been particularly reported to deliver signals to receptors on endothelial cells and induce a proangiogenic response [32,198]. Of note, VEGF isoform (VEGF189) bound ...
Immune checkpoint inhibitors (ICI) have revolutionized treatment for various cancers; however, durable response is limited to only a subset of patients. Discovery of blood-based biomarkers that reflect dynamic change of the tumor microenvironment, and pr