13. Sullivan RJ. Efficacy and Safety of Entinostat (ENT) and Pembrolizumab (PEMBRO) in Patients with Melanoma Previously Treated With Anti-PD-1 Therapy. AACR2019. 14. Ascierto PA, Bono P, Bhatia S, Melero I, Nyakas MS, Svane IM, ...
Evolving immunogenicity assay performance expectations and a lack of harmonized anti-drug antibody validation testing and reporting tools have resulted in
Anti-CD38 antibodies exert their therapeutic effects via direct effector mechanisms on MM cells (i.e., CD38 enzymatic inhibition, direct induction of apoptosis) and through Fc-dependent immune mechanisms, including antibody-dependent cellular cytotoxicity (ADCC), complement-directed cytotoxicity (CDC), ...
Brain inflammation is a major factor in epilepsy, and the high mobility group box-1 (HMGB1) protein is known to contribute significantly to the generation of seizures. Here, we investigated the therapeutic potential of an anti-HMGB1 monoclonal antibody (mAb) in epilepsy. anti-HMGB1 mAb attenuated...
Ananti-idiotypic antibody(anti-ID Ab) can recognize and bind to the idiotypic center of another antibody. Anti-idiotype antibodies are widely used in therapeutic drug development, such as immunogenicity assessments and pharmacokinetic/pharmacodynamics (PK/PD) studies. ...
Anti-SIRPα Antibody (Biosion): 一种SIRPα抑制剂药物,由Biosion, Inc. (博奥信生物技术(南京)有限公司)公司最早进行研发,目前全球最高研发状态为终止,作用机制: SIRPα抑制剂(信号调节蛋白α抑制剂),治疗领域: 肿瘤,皮肤和肌肉骨骼疾病。
This is the first report, to our knowledge, to evaluate the association between RAGE signalling and pathologic conditions in a rat model of crush injury including systemic inflammation to assess the potential therapeutic effects of therapy with anti-RAGE antibody. The goal of this study was to dev...
Human ErbB2/Her2 (Research Grade Trastuzumab Biosimilar) Antibody Summary Species Reactivity Human Specificity Detects human ErbB2/Her2 in direct ELISAs. This non-therapeutic antibody uses the same variable region sequence as the therapeutic antibody Trastuzumab. This product is for research use...
The antibody is specific for digoxin, a cardiac glycoside derived from the foxglove plant. Digoxin is administered for the therapeutic treatment of heart conditions such as atrial fibrillation, atrial flutter and heart failure, an acts by inhibiting the Na+/K+ ATPase. However, the drug has a ...
therapeutic proteins are conjugated with PEG to slow down their clearance from circulation and improve bioavailability. PEG antibodies can be a vital tool for propelling therapeutics to market by serving as a positive control anti-drug antibody,measuring clearance of a drug,or simply as a QA ...