Therapies using TGF-尾 inhibitors and/or PD-1 inhibitors are disclosed. These drugs at certain doses (including flat dosing) and regimens can be used to treat or prevent proliferative diseases such as solid tumors, including pancreatic cancers. Further combination and uses thereof are also ...
Over a dozen small molecules inhibit the kinase activity of TGF-beta receptors. Several commonly used drugs appear to have unanticipated anti-TGF-beta activity and may therefore have a role in antifibrotic therapy. Because TGF-beta has important physiological functions, inhibiting its activity might ...
R- and S-isomers of nonsteroidal anti-inflammatory drugs differentially regulate cytokine production Eur Cytokine Netw, 11 (2000), pp. 185-192 View in ScopusGoogle Scholar 43 DS Steinbrech, BJ Mehrara, NM Rowe, et al. Gene expression of TGF-beta, TGF-beta receptor, and extracellular matrix...
Targeted tumor therapy with the compound AP 12009 directed against TGF-b2 in high-grade glioma patients: Results of a phase II study Targeted cancer therapies use drugs that block the growth and spread of cancer by interfering with specific target molecules that play a key role in the cancer ...
Preparation, characterization, and in-vitro cytotoxicity of nanoliposomes loaded with anti-tubercular drugs and TGF-β1 siRNA for improving spinal tubercul... These findings suggested that HRZ-loaded nanoliposomes with siTGF-β1 have the potential for improving spinal tuberculosis chemotherapy via nano...
TGF-β: Transforming growth factor β TNF-α: Tumor necrosis factor α uPA: Urokinase plasminogen activator uPAR: Urokinase plasminogen activator receptor VCAM-1: Vascular cell adhesion molecule-1 VEGF: Vascular endothelial growth factor ...
[130]. It is also found to inhibit the serum levels of inflammatory factors including TGF-β, TNF-α and IL-1 in 68 patients with AMI [131]. In LAD ligation rats, GXD improved cardiac function, reduced infarct size and pro-inflammatory factor levels (such as TNF-α, IL-1β and NF-...
Transforming growth factor-beta 1, 2, 3 (TGF-β1, TGF-β2, TGF-β3) are pleiotropic cytokines markedly upregulated in HF, its induction being associated with cardiac injury, repair and remodeling (cardiomyocyte apoptosis, hypertrophy, and fibrosis) [189]. In experimental models, TGF-β1, TG...
Liang Y, Hou M, Kallab AM, Barrett JT, El Etreby F, Schoenlein PV: Induction of antiproliferation and apoptosis in estrogen receptor negative MDA-231 human breast cancer cells by mifepristone and 4-hydroxytamoxifen combination therapy: a role for TGFbeta1. Int J Oncol. 2003, 23 (2): ...
et al. The immunosuppressive factors IL-10, TGF-beta, and VEGF do not affect the antigen-presenting function of CD40-activated B cells. J. Exp. Clin. Cancer Res. 31, 47 (2012). CAS PubMed PubMed Central Google Scholar Kondo, E. et al. CD40-activated B cells can be generated in ...