Olanzapine (OLA), is prescribed as an anti-psychotic medicine in schizophrenia patients. In this study, the protective effect of OLA against genotoxicityand apoptosis induced by ionizing radiation in human healthy lymphocytes was evaluated. At first, the antioxidant activities of OLA were assayed by ...
HPLC analysis of olanzapine 1, a known anti-psychotic drug, showed impurity peaks ranging from 0.05 to 0.15% during process development. These samples were analyzed by LCMS and the peaks were identified at m/z 230, 341, 511, 326, 361 and 329. All six impurities were synthesized individually...
4.Effect of traditional medicine on amenorrhea caused by antipsychotics in female patients with schizophrenia中成药治疗抗精神病药物引起女性精神分裂症患者闭经的研究 5.Health economic impact of novel versus older anti-psychotic medications in schizophrenia.;抗精神病药物治疗精神分裂症的卫生经济学比较分析 6....
Mitochondrial pathology has been implicated in the pathogenesis of psychotic disorders. A few studies have proposed reduced leukocyte mitochondrial DNA (mtDNA) copy number in schizophrenia and bipolar disorder type I, compared to healthy controls. However, it is unknown if mtDNA copy number alteration ...
Central anticholinergic effects of psychoactive drugs involve features such as memory impairment, confusion, disorientation, delirium, visual hallucinations, and worsening of preexisting psychotic symptoms. Combination of psychoactive drugs with anticholinergic effects, such as a tricyclic antidepressant, and a...
olanzapine; risperidone; elderly; cohort study INTRODUCTION In the US, second-generation antipsychotic medications (SGAs) introduced after clozapine quickly became the treatment of choice for psychotic disorders, and have subsequently been used and approved for several non- psychotic disorders as well. Th...
The complex title of this chapter reflects several basic points about this important class of medicines. They are now the most widely used psychotropic drugs, and even more in general medicine than in psychiatry [171, 384, 576]. Their origins in the 1950
by University of Pennsylvania School of Medicine The potential for harmful side effects associated with anti-psychotic medications for treating schizophrenia is a frustration for mental-health professionals who must balance this with the positive benefits of drugs. For example, the issue of the ...
The electrochemical degradation of dilute aqueous solutions of olanzapine (OL), using boron-doped diamond (BDD) anodes as electrocatalysts, was investigated. The studies were carried out in a single-compartment electrochemical cell at three different current densities (10, 30, and 50mA cm 2 ), 25...
(SGAs) might induce OCS, but investigations of large samples integrating psychopathology, neuropsychology and psychopharmacology are missing.MethodWe stratified 70 patients with schizophrenia according to their mode of antipsychotic treatment: clozapine and olanzapine (group I) compared with aripiprazole and ...