The anti- N -methyl-D-aspartate receptor (NMDAR) encephalitis is a multi-phasic immune-mediated syndrome with a unique evolution of clinical features. Patients usually present with psychiatric symptoms such as anxiety, delusions and paranoia followed by disturbance of speech and obtundation. So...
Reversible brain atrophy in anti-NMDA receptor encephalitis: a long-term observational study The long-term neuroimaging correlates of clinical recovery have not been described in anti- N -methyl- d -aspartate receptor (NMDAR) encephalitis. The aim ... T Iizuka,S Yoshii,S Kan,... - 《Journal...
Three possible scenarios accounting for the immunopathogenesis of anti-NMDAR encephalitis are presented, with the most probable one being that of paraneoplastic autoimmunity. Future efforts in this disorder should focus on elucidating the mechanisms that contribute to initiation of this antibody response, ...
Brain immunohistopathological study in a patient with anti-NMDAR encephalitis Background and purpose: Anti-N-methyl-d-asparate (NMDA) receptor encephalitis is thought to be antibody-mediated. To perform an immunohistopathological... J.-P.,Camdessanché,N.,... - 《European Journal of Neurol...
NMDAR IgG antibody prevalence in our cohort was consistent with previous reports. Antibody-positivity was found in individuals of all ages and gender, with or without tumor. This test is practical for the evaluation encephalitis and may be relevant for managing disease....
Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a clinically heterogeneous disorder characterized by epileptic seizures, psychosis, dyskinesia, consciousness impairments, and autonomic instability. Symptoms are always various. Sometimes it presents in milder or incomplete forms. We report 4 cases...
1) These findings indicate that "juvenile acute nonherpetic encephalitis" or a subset of this disorder is mediated by an antibody-associated immune response against NR1/NR2 heteromers of the NMDA receptor (NMDAR). 2) Our patients' clinical features emphasize that anti-NMDAR encephalitis is severe...
There are currently no guidelines that exist on the management of anti NMDA receptor encephalitis in COVID patients. The duration and course of the disease has not been well established and the frequency of flares has not been established. Treatment of NMDAR encephalitis consists of immunotherapy wh...
Clinical experience and laboratory investigations in patients with anti-NMDAR encephalitis Lancet Neurol (2011) AJGleichmanet al. Anti-NMDA Receptor encephalitis antibody binding is dependent on amino acid identity of a small region within the GluN1 amino terminal domain ...
Fecal samples were collected immediately upon the admission of patients who presented acute psychiatric symptoms, seizures, or focal neurological signs and were susceptible to anti-NMDAR encephalitis. Patients did not receive any immune therapies before anti-NMDAR antibody encephalitis was confirmed by ...