Targeting Nectin-4 in bladder cancer. Cancer Discov. 7, OF3 (2017). https://doi.org/10.1158/2159-8290.CD-NB2017-095. Challita-Eid, P. M. et al. Enfortumab Vedotin antibody-drug conjugate targeting Nectin-4 is a highly potent therapeutic agent in multiple preclinical cancer models. ...
Nectin-4-targeted immunoSPECT/CT imaging and photothermal therapy of triple-negative breast cancer. PMID: 35614462 Antibody-based in vivo leukocyte label for two-photon brain imaging in mice. PMID: 35637871 In vivo application of mAb directed against the gammadelta TCR does not deplete but generate...
in CAR T cells from whole bone marrow restimulated ex vivo with leukemia. Data are shown as mean ± s.d.f–h, Intranuclear TF staining of IRF4 (f; exactPvalue of 0.0287), EOMES (g; exactPvalues from left to right:P = 0.0133,P = 0.0058 andP = 0.0017) or T-...
The terms “CTLA-4,”“CTLA-4 protein,” and “CTLA-4 antigen” are used interchangeably herein to refer to human CTLA-4, or any variants (e.g., splice variants and allelic variants), isoforms, and species homologs of human CTLA-4 that are naturally expressed by cells, or that are ex...
The role of nectins in different types of cell-cell adhesion. J Cell Sci. 2012;125(Pt 16):3713–3722. doi:10.1242/ jcs.099572 5. Sloan KE, Eustace BK, Stewart JK, et al. CD155/PVR plays a key role in cell motility during tumor cell invasion and migration. BMC Cancer. 2004;4(1...
On the other hand, junctional proteins at the germ cell side tend to decrease (e.g., nectin-3, afadin, and lamininγ3) (Lee et al. 2004; Siu and Cheng 2004) following adjudin treatment. We speculate that following adjudin administration, Sertoli cells respond by expressing more junctional ...
Cytochalasin D K562, HCT-116, and Hep-G2 Enhances NK cell IFN-γ production and cytotoxic activity; induction of NKG2D, DNAM1, and NKp30 expression on NK cells Induction of ULBPs, MICA, PVR, Nectin-2 and B7-H6 [86] Nocodazole No effect on NK cell functions; induction of NKG2D, DNA...
On the RetroNectin-coated 12-well transduction plate, cells were added. The plate was incubated for 14 h in 5% CO2 at 37 °C for pre-stimulation. After pre-stimulation, 1 ml of viral particles was added. Plate incubated for 24 h in 5% CO2 at 37 °C. After 24 h cells were ...
Activated T cells were then transduced with a retrovirus to co-express HER2-BBz-CAR and blue fluorescent protein (BFP) on days 3 and 4 using Retronectin (Takara) coated plates, and cultured in 300 IU/ml recombinant human IL-2. Media and IL-2 were changed every 2 days. Transduction ...
(Table1and Supplementary Table1). Nectin-4 is overexpressed in many cancers and is mainly investigated as antibody-drug conjugate (ADC) target, i.e., as a tumor-associated antigen (TAA). Anti-TIGIT mAbs evaluated in phase III trials include vibostolimab, tiragolumab, ociperlimab, and dom...