作者: $百奥泰(SH688177)$2025年4月16日新增专利信息:1. EP4538291 - ANTI-NECTIN-4 ANTIBODY, AND ANTIBODY-DRUG CONJUGATE AND USE THEREOF 1. EP4538291 - NECTIN-4抗体的抗体,以及抗体药物偶联物及其应用 Abstract 摘要 (EN) (EN) Disclosed herein are an anti-Nectin-4 antibody, an antibody-drug con...
The present invention relates to an antibody-drug conjugate comprising a monoclonal antibody or an antigen-binding fragment thereof wherein the monoclonal antibody or the antigen-binding fragment thereof binds to Nectin-4 and wherein the drug is an amatoxin, particularly α-amanitin....
Targeting Nectin-4 in bladder cancer. Cancer Discov. 7, OF3 (2017). https://doi.org/10.1158/2159-8290.CD-NB2017-095. Challita-Eid, P. M. et al. Enfortumab Vedotin antibody-drug conjugate targeting Nectin-4 is a highly potent therapeutic agent in multiple preclinical cancer models. ...
96,112CD155 has the highest affinity to TIGIT and lower affinity to CD96 and CD226. CD112 binds TIGIT and CD226 less strong than CD155, and does not bind CD96.96,112CD111 only interacts with and stabilizes CD155.113Nectin-4 only interacts with TIGIT...
Nectin-4-targeted immunoSPECT/CT imaging and photothermal therapy of triple-negative breast cancer. PMID: 35614462 Antibody-based in vivo leukocyte label for two-photon brain imaging in mice. PMID: 35637871 In vivo application of mAb directed against the gammadelta TCR does not deplete but generate...
The role of nectins in different types of cell-cell adhesion. J Cell Sci. 2012;125(Pt 16):3713–3722. doi:10.1242/ jcs.099572 5. Sloan KE, Eustace BK, Stewart JK, et al. CD155/PVR plays a key role in cell motility during tumor cell invasion and migration. BMC Cancer. 2004;4(1...
Cytochalasin D K562, HCT-116, and Hep-G2 Enhances NK cell IFN-γ production and cytotoxic activity; induction of NKG2D, DNAM1, and NKp30 expression on NK cells Induction of ULBPs, MICA, PVR, Nectin-2 and B7-H6 [86] Nocodazole No effect on NK cell functions; induction of NKG2D, DNA...
On the other hand, junctional proteins at the germ cell side tend to decrease (e.g., nectin-3, afadin, and lamininγ3) (Lee et al. 2004; Siu and Cheng 2004) following adjudin treatment. We speculate that following adjudin administration, Sertoli cells respond by expressing more junctional ...
Fabre-Lafay S, Garrido-Urbani S, Reymond N, Goncalves A, Dubreuil P, Lopez M (2005) Nectin-4, a new serological breast cancer marker, is a substrate for tumor necrosis factor-alpha-converting enzyme (TACE)/ADAM-17. J Biol Chem 280:19543–19550. https://doi.org/10.1074/jbc.M410943200...
On days +1 and +2 post-activation, T cells were spinoculated with retroviral supernatant on plates coated with Retronectin (Clontech, T100B). On day +3, beads were removed and %GFP was measured by flow cytometry to assess the efficiency of gene transfer. Cells were either used fresh or ...