Pembrolizumab (anti-PD-1)是一种有效的、高选择性的、人源IgG4-kappa单克隆抗体,同时也是抑制剂,靶向PD-1,具有潜在的免疫检查点抑制活性;MW:146.286 KD。 纯度:99%蛋白浓度:15.94mg/ml内毒素:<1EU/mg 产品名称:selleck Pembrolizumab (anti-PD-1) 单抗 ...
selleck品牌代理商——买selleck抑制剂,抗体,化合物库,就来华雅思创 产品介绍: Anti-mouse PD-L1 (B7-H1)-InVivo (克隆号:10F.9G2)单克隆抗体可与小鼠PD-L1(也称为B7-H1、CD274)发生反应。10F.9G2 抗体已被证明可以阻断 PD-L1 和 PD-1 之间以及 PD-L1 和 B7-1 (CD80) 之间的相互作用 ...
Antibodies used in immunoblotting were as follows: mouse monoclonal antibody anti-HnRNP L (1:2000; Abcam #ab-6106), rabbit monoclonal antibody anti-PD-L1 (1:1000; Abcam #ab-213524), mouse monoclonal antibody anti-GAPDH (1:1000; Abcam #ab-8245), rabbit monoclonal antibody anti-SLC7A11 (...
AIL significantly inhibited the metastasis and invasion of the human and mouse melanoma cell lines. To further validate the antitumor effects of AIL, we inoculated B16-F10 mouse melanoma cells into C57BL/6 mice for an in vivo study. As shown in Fig.2E-G, AIL treatment significantly...
PD-L1 protein levels increased dramatically in Ampkα1/α2 double-knockout (DKO) mouse embryonic fibroblasts (MEFs) compared with wild-type (WT) MEFs (Figure 3A). Furthermore, knockout of both AMPKα1 and α2, but neither alone, could increase PD-L1 protein abundance, but not PD-L1 ...
YTHDF2 interacts with IKZF1/3, which is important for sustained transcription of their target genes. Accordingly, immunotherapy-induced efficacy could be largely restored in YTHDF2-deficient T cells through combinational use of IKZF1/3 inhibitor lenalidomide in a mouse model. Thus, YTHDF2 ...
IL-21 has been reported to synergize with IL-7 to enhance mouse and human CD8+ T-cell expansion and function in vitro36,38,55. In agreement with this, we observed that IL-21/IL-7 LNP induced CD8+ T-cell expansion and enhanced their capacity to produce granzyme B. IL-21 has been ...
We previously reported that dendritic cell (DC)-based vaccines targeting antigens expressed by tumor-associated vascular endothelial cells (VECs) and pericytes effectively control tumor growth in translational mouse tumor models. In the current report, w
[24,25]. The tetraspanin CD9 could form cell-surface complexes with TMPRSS2 to facilitate MERS-CoV entry and infection of mouse lungs in vivo [24]. MERS-CoV and SARS-CoV utilized tetraspanin-enriched microdomains on the host cells to facilitate proteolytic priming and virus–cell membrane ...
The outcome of the calculation is numerically represented as 0.236.selleck chemicalsModels, through simulation and prediction, offer valuable insights into the behavior of systems.medicinal leechWhile trajectory-based metrics were considered, they ultimately did not show any statistically significant associatio...