PHase II trial of anti-IL-6 receptor antibody (MRA) for systemic-onset juvenile idiopathic arthritis. Yokota S,Imagawa T,Mori M, et al. Autoimmunity Reviews . 2004Yokota S, Imagawa T, Mori M, Miyamae T, Nishimoto N, Kishimoto T. Phase II trial of anti-IL-6 receptor antibody (MRA) ...
In this study, we analysed the IL-6 responses of fibroblasts isolated from human colon cancer and a xenograft colon cancer cell line, with a focus on angiogenesis. Materials and methods Agents Anti-IL-6 receptor antibody, MRA (tocilizumab: anti-human IL-6 receptor antibody) and MR 16-1 (...
ObjectiveTo investigate the safety and efficacy of MRA, a recombinant human anti–interleukin-6 (anti–IL-6) receptor monoclonal antibody of the IgG1 subclass that inhibits the function of IL-6, in patients with established rheumatoid arthritis (RA).MethodsA randomized, double-blind, placebo-contr...
Figure 1. Blockade of IL-6 signals by anti-IL-6 receptor antibody (MRA, Tocilizumab). h, human; IL, interleukin; sIL-6R, soluble interleukin-6 receptor.(Cited with permission from Kishimoto (2006)). On June 2005, Tocilizumab was approved in Japan for Castleman’s disease (a rare benign...
Interleukin 6-mediated endothelial barrier disturbances can be attenuated by blockade of the IL6 receptor expressed in brain microvascular endothelial cells. Transl Stroke Res. 2018;9(6):631–42. Article CAS PubMed Google Scholar Spangenberg E, Severson PL, Hohsfield LA, Crapser J, Zhang J, ...
Here, using high-throughput flow cytometry as well as bulk and single-cell RNA-sequencing and B-cell-receptor-sequencing analysis of B cells temporally during B16F10 melanoma growth, we identified a subset of B cells that expands specifically in the draining lymph node over time in tumour-...
[159]. Moreover, a transversal study in obese patients with T2D revealed that metformin treatment diminished the activation of the NOD-like receptor thermal protein domain associated protein 3 inflammasome complex in VAT and associated pro-inflammatory factors TNF-α, IL-6, IL-1β and MCP-1, ...
APL(antiphospholipidantibody) AP.1(activator protein・ 1) ANX2(AnnexinA2) 132GPI(p-2-glycoprotein I) DEPC(diethylpyrocarbonate) HRP(horseradish peroxidase) IRAKs(IL.1 receptor-associated kinases) LPS(Lipopolysaccharide) MyD88(myeloid differentiationfactor88) MAPK(mimgen-activatedprotein kinase) NF....
Tocilizumab, which is additionally referred to as myeloma receptor antibody (MRA), is a recombinant humanised antibody of the IgG1 subclass which functions as an IL-6 receptor inhibitor [71]. It is mostly used to treat autoimmune diseases such systemic juvenile idiopathic arthritis and rheumatoid ...
(conjugated to potent antimicrotubule agent DM1),10 and anti-HM1.24.11,12 Murine anti-CD138 mAb conjugated with DM1 (B-B4-DM1),13 anti-HLA-A (2D7-DB),14 anti–IL-6 receptor (NRI),15 as well as anti–beta2-microglobulin16 have also demonstrated significant antitumor activity in ...