Introduction Autoantibodies to extracellular epitopes of neurons and associated neurological disorders, especially autoimmune limbic encephalitis (LE), are increasingly recognized. GABA b receptor antibody associated autoimmune LE often presents with refractory seizures. Timely recognition and diagnosis are ...
and -amphiphysin antibodies by using a commercially available line blot assay (Euroimmun, Germany), and for anti-NMDA-type glutamate receptor, anti-AMPA-type glutamate receptor, anti-GABA-B receptor, anti-CASPR2, anti-LGI1, anti-AQP4, and anti-glycine receptor antibodies using a panel of reco...
and -amphiphysin antibodies by using a commercially available line blot assay (Euroimmun, Germany), and for anti-NMDA-type glutamate receptor, anti-AMPA-type glutamate receptor, anti-GABA-B receptor, anti-CASPR2, anti-LGI1, anti-AQP4, and anti-glycine receptor antibodies using a panel of reco...
GABA-containing secretory vesicles. The two isoforms appear to have distinct intraneuronal distribution in the brain. GAD65 has been identified as an autoantigen in insulindependent diabetes mellitus (IDDM) and stiff-man syndrome (SMS), IDDM is an autoimmune disease that results from T cell ...
We show that human astrocytes are GABA... M Lee,C Schwab,PL Mcgeer - 《Glia》 被引量: 147发表: 2015年 Dual impairment of GABAA- and GABAB-receptor-mediated synaptic responses by autoantibodies to glutamic acid decarboxylase. Anti-glutamate decarboxylase autoantibodies (GAD-A) are associated ...
demonstrated that IL-6 reduced the frequency of spontaneous inhibitory postsynaptic currents and GABA-induced currents in the spinal cord (Kawasaki et al., 2008). Experimental autoimmune encephalomyelitis (EAE) is a well-established animal model of the CNS autoimmune disease, and causes widespread CNS...
Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by multi-organ involvement and the presence of autoantibodies, pathogenic factors that can serve as diagnostic biomarkers. The current research has been focusing on exploring specific autoantigens with clinical relevance for ...
Small, soluble metabolites not only are essential intermediates in intracellular biochemical processes, but can also influence neighbouring cells when released into the extracellular milieu1–3. Here we identify the metabolite and neurotransmitter GABA a
Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is a treatable autoimmune disorder characterized by prominent neuropsychiatric symptoms that predominantly affects children and young adults. In this review, we discuss the pathogenic mechanisms and immunologic triggers of anti-NMDAR encephalitis,...
A prevailing idea associates NMDAR hypofunction in schizophrenia primarily to synapses onto GABAergic interneurons23, while the role of NMDARs in working memory has been emphasized in synapses between pyramidal neurons1,2,21. Alternatively, NMDARs could be involved in mechanisms directly associated ...