United States Patent 8226989 Abstract: Herbal compositions having anti-adipocyte fatty acid-binding protein (aP2), anti-5-lipoxygenase-activating protein (FLAP) and anti-Cysteinyl Leukotriene (CysLT)-1 receptor expression activity contain an extract ofBoswellia serrata. More particularly, these herbal ...
et al. Macrophage-derived AIM is endocytosed into adipocytes and decreases lipid droplets via inhibition of fatty acid synthase activity. Cell Metab. 11, 479–492 (2010). Article CAS PubMed Google Scholar Guignabert, C. et al. Tie2-mediated loss of peroxisome proliferator-activated receptor-...
46, resulting in reduced adipocyte size47,48. Notably, SCFAs play a potential role in decreasing fat accumulation in the adipose tissue by accelerating the oxidation of fatty acids in HFD-induced obese
United States Patent 8802932 Abstract: Compositions and methods for protecting a plant from a pathogen, particularly a fungal pathogen, are provided. Compositions include amino acid sequences, and variants and fragments thereof, for family members of a novel family of antipathogenic polypeptides. ...
positions in the N-terminal side of human thymidylate synthase; an antihuman thymidylate synthase monoclonal antibody recognizing an epitope present in the amino acid region ranging from the N-terminus to the 61-position of human thymidylate synthase; and hybridomas producing these monoclonal antibodies...
Furthermore, estradiol-derived selective ERβ agonists significantly inhibit lipogenesis in adipose tissue of obese female Wistar rats through the downregulation of SRE binding protein 1 (SREBP-1), fatty acid synthase (FASN), and lipoprotein lipase (LPL)28. ERβ activation also stimulates skeletal ...
Patent WO 2015070224 Another particular MDM2 inhibitor is AM-7209 (Compound C herein), which is disclosed in U.S. provisional patent application number 61/770,901, filed February 28, 2013. (See Example No. 5 therein and below). AM-7209 has the following chemical name and structure: 4- (...
et al. Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors. Science 288, 2379–2381 (2000). Article Google Scholar Brown, N.F., Esser, V., Foster, D.W. & McGarry, J.D. Expression of a cDNA for rat liver carnitine palmitoyltransferase I in yeast...
United States Patent 11420995 Abstract: Lysosomally accumulated substances that release a nitroxy group, or a short chain fatty acid or a product of anaerobic metabolism or a thiol or a sulfide often from an ester or similar labile linkage have anti-inflammatory, anti-cancer and anti-bacterial ...
United States Patent Application 20160081966 Kind Code: A1 Abstract: The present invention discloses an antihypoxic pharmaceutical composition and application thereof. The pharmaceutical composition contains vinpocetine and L-carnitine or a derivative thereof and a pharmaceutically acceptable salt thereof, and...