Anti—dsDNA自身抗体,肿瘤,系统性红斑狼疮(sLE) DNA,亲和力,凋亡 抗双链DNA(anti.double.strandedDNA,anti.dsDNA)自身抗体是诊断系统 性红斑狼疮(systemiclupuscrythematosus,SLE)的主要标志,在系统性自身免 疫性疾病的发生发展和免疫病理中起重要作用。但有研究发现,在一些肿瘤病人 ...
24. A method for generating a calibration curve of the chimeric antibody of claim 1, comprising: contacting the chimeric antibody at a first known amount with dsDNA or chromatin in a first solution, detecting binding of the chimeric antibody to the dsDNA or chromatin, and assigning a first det...
Positive LR for this test was 4.21, and negative LR was 0.42. The area under anti-DNase I ROC curve had reached 0.774 and there was no significant difference between this AUC and the anti-dsDNA AUC.Conclusion For the discrimination between SLE and commonly seen autoimmune rheumatic diseases ...
systemic lupus erythematosus; T cells; gene expression; tolerance/suppression Introduction Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by multiorgan damage and a variety of clinical symptoms associated with the produc- tion of autoantibodies against dsDNA and other nuclear and...
When the ANA test is positive, other tests are required to identify which protein(s) the antibodies are attacking such as the anti-dsDNA test and the ENA panel.A positive ANA test means that a person may have an autoimmune disease, depending on the titre....
(dsDNA)20. The regulation of some of these genes involves unique promoters designated Frpo, which adopt a secondary structure that mimics a double-strand conformation, allowing recognition by the host RNA polymerase6,17. Thus, Frpofunctions as a single-strand promoter, enabling early expression ...
The growing field of immunometabolism has taught us how metabolic cellular reactions and processes not only provide a means to generate ATP and biosynthetic precursors, but are also a way of controlling immunity and inflammation. Metabolic reprogramming
(Fig.6E). Next, we used a 40 bp dsDNA substrate carrying a single BREX/AluI and a single Dam site in the in vitro methylation reaction with wild-type BrxX or BrxXY511Amutant. Dam methyltransferase was used as a positive control. While Dam methylation was complete after overnight ...
1a & b). Dialysate decorin level showed a positive correlation with dialysate CA125 level (Fig. 1c). Table 1. Characteristics of PD patients. Empty CellStable PD patients (n = 72)PD patients with peritonitis (n = 31)P value Gender (male: female): 36: 36 13: 18 0.522c aAge (years...
(1990)) and nucleic acid based sequence amplification (NASBA). The latter two amplification methods involve isothermal reactions based on isothermal transcription, which produce both single stranded RNA (ssRNA) and double stranded DNA (dsDNA) as the amplification products in a ratio of about 30 or...