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self-renewal via 尾-catenin accumulation, which leads to the promotion of proliferation by lymphoid enhancer factor (LEF)/T-cell factor (TCF)-mediated cyclin D1 expression and at the same time to the inhibition of neuronal differentiation by 尾-catenin-mediated potentiation of Notch signaling. To...
Type-A Arabidopsis response regulators are partially redundant negative regulators of cytokinin signaling. Plant Cell Online 16, 658–671 (2004). Article CAS Google Scholar Boudolf, V. The plant-specific cyclin-dependent kinase CDKB1;1 and transcription factor E2Fa-DPa control the balance of ...
Signaling through 4-1BB in CD8+ T cells leads to proliferation, enhanced survival, cytokine production, improved memory formation, and altered metabolism11,12,13,14,15. Treating mice with agonist ɑ4-1BB antibodies as a monotherapy or in combination therapies is highly efficacious in several ...
G-protein coupled estrogen receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Stimulates cAMP production, calcium mobilization and tyrosine kinase Src inducing the release of heparin-bound epidermal grow...
The activated Wnt signaling pathway leads to the expression of proteins involved in cell survival and proliferation, such as cyclins, c-myc, and sequentia [65]. In our study, rbNPs reduced the expression of β-catenin and cyclin D1 in colon26 cells (Fig. 3D) but did not affect β-...
Cyclin-dependent kinase 4/6 pRb: Phosphorylated retinoblastoma PBMCs: Peripheral blood mononuclear cells RRM: RNA recognition motif CCR: Coiled coil region UPS: Ubiquitin–proteasome system CTLs: Cytotoxic T lymphocytes FBXW11: F-box and WD repeat domain containing 11 SCF: SKP1-CUL1-...
demonstrated the involvement of cyclin B1 in cancer cell differentiation, growth, apoptosis, and resistance to chemotherapy [223,224,225,226]. In 88% of the patients with CRC, cyclin B1 was found to be overexpressed compared to the non-neoplastic colorectal mucosa cells [225]....
et al. The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level. Oncogene 27, 3576–3586 (2008). PubMed Google Scholar Hirsch, H. A., Iliopoulos, D. & Struhl, K. Metformin inhibits the inflammatory response associated with...
Notably, previous studies reported that the specific inhibition of GRP78 expression suppressed G1/S transition-related cyclins (D1, E1, and E2) and cyclin-dependent kinase (CDK4 and CDK6) protein expression58. Therefore, the molecular mechanism by which GRP78 inhibitors induce CRC cell cycle ...