产品名称 HRP Anti-Cyclin E2抗体[EP454Y] 品牌 艾博抗Abcam 货号 ab200425 描述 HRP兔单克隆抗体[EP454Y] to Cyclin E2 经测试应用 适用于: WB 种属反应性 与反应: Human 免疫原 Synthetic peptide. This information is proprietary to Abcam and/or its suppliers. 阳性对照 WB: Jurkat whole ce...
PIERCE MA112570 Anti-Cyclin A Monoclonal Antibody 100 µg 3183 PIERCE MA112583 Anti-Renal Cell Carcinoma Monoclonal Antibody 100 µg 3183 PIERCE MA112584 Anti-Exosome component 1 Monoclonal Antibody 100 µg 3183 PIERCE MA112588 Anti-Cytokeratin 14 Monoclonal Antibody 100 µg 3183 PIE...
Proteasomal degradation of PD-L1 has been reported to be promoted by cyclin D-CDK4-mediated phosphorylation followed by Cullin 3SPOP-dependent ubiquitination7, as well as glycogen synthase kinase 3-β (GSK3β)-mediated phosphorylation followed by β-TrCP-dependent ubiquitination8. However, the dynam...
The activated Wnt signaling pathway leads to the expression of proteins involved in cell survival and proliferation, such as cyclins, c-myc, and sequentia [65]. In our study, rbNPs reduced the expression of β-catenin and cyclin D1 in colon26 cells (Fig. 3D) but did not affect β-...
Notably, previous studies reported that the specific inhibition of GRP78 expression suppressed G1/S transition-related cyclins (D1, E1, and E2) and cyclin-dependent kinase (CDK4 and CDK6) protein expression58. Therefore, the molecular mechanism by which GRP78 inhibitors induce CRC cell cycle ...
G-protein coupled estrogen receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Stimulates cAMP production, calcium mobilization and tyrosine kinase Src inducing the release of heparin-bound epidermal grow...
In that study, elevated ROS upregulated the cyclin-dependent kinase inhibitor, p16INK4A/Rb, which resulted in defective stem cell function. Based on those data, AM was thought to be essential for autonomous regulation of HSCs in the murine fetal liver through its effects on intracellular iron ...
cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor....
Mechanistically, SL4 reduces the expression of cyclin A2 and cdc25C and decreases the activity of the cdc2/cyclin B1 complex. Notably, SL4 treatment resulted in an obvious increase in p21 mRNA and protein levels through activation of MAPK signaling pathways, but not the TGF-β pathway. SP...
Specifically, Wnt-TCF signaling components were altered through increasing the levels of APC, GSK-3β and Axin, and decreasing β-Catenin, p-GSK3β and CK1. The activity of the Wnt transcription factor TCF/LEF and its downstream targets Cyclin D1 and c-MYC were also reduced, and ...