CD8+T cells cannot differentiate into CTLs. As a result, strategies have been created to mimic CD3ζ signaling without MHC-I: peptide-mediated TCR triggering. These depend on agonistic antibodies or cross-linked antibody fragments
We also measured cytokine (IL-2) secretion of Jurkat T-CD16A cells bound to BiKEs after cross-linking, which was achieved by either bivalent mouse anti-FLAG antibody or by 293T-gp160SC cells. Co-incubation of Jurkat T-CD16A cells with BiKEs opsonized 293T-gp160SC cells resulted in relea...
found a significant association with incidence of cancer (− 8%). However, the number of studies taken in account was limited: 2 cross-sectional and 3 prospective studies for a total of 38,053 patients. Moreover, no
Structural studies by X-ray crystallography and in silico modeling provided a mechanistic basis for the effect of the C6″ substitution on enhancing presentation of AH10-7 by human CD1d. Our results, along with another recently published study of combining C6″ substitutions with other Th1-biasing...
BV510 anti-CD19, APC anti-CD93, BV421 anti-CD21/CD35, and phycoerythrin (PE) anti-CD1d (all BioLegend) were used to differentiate between CD19+/CD93−/CD21int/CD1dlo follicular B cells and CD19+/CD93−/CD21hi/CD1dhi marginal zone B cells. Plasma cells were stained with BV...
Transforming growth factor-beta production and myeloid cells are an effector mechanism through which CD1d-restricted T cells block cytotoxic T lymphocyte-mediated tumor immunosurveillance: Abrogation prevents tumor recurrence. J. Exp. Med. 2003, 198, 1741–1752. [Google Scholar] [CrossRef] [PubMed]...