The anti-CD147 antibody provided by the invention shows high tumor effectiveness independent of functionAnesthetic. The present invention provides a pharmaceutical component including this anti-CD147 antibody. The present invention provides a method for treating tumors with such anti-CD147 antibodies and...
Presently, two receptors have been identified for SARS-CoV-2: human angiotensin-converting enzyme 2 (hACE2) and CD147. hACE2 acts as the major entry receptor for SARS-CoV-2 through its interaction with S-RBD. CD147, a type I transmembrane protein involved in the infection of some ...
Kim Y, Choi JW, Lee JH, Kim YS (2015) Expression of lactate/H(+) symporters MCT1 and MCT4 and their chaperone CD147 predicts tumor progression in clear cell renal cell carcinoma: immunohistochemical and the cancer genome atlas data analyses. Hum Pathol 46(1):104–112 Article CAS PubMed...
Activated T cells express a number of markers including CD25 (IL-2 receptor α), CD69, CD71, CD147, and HLA-DR. Van Dijk et al have demonstrated that depletion of allo-antigen–activated T cells using a cocktail of anti-CD25, -CD69, -CD71, and –HLA-DR microbeads with the magnetic...
Bregs have been reported to promote tumor progression by interacting with tumor cells, by suppressing anti-tumor responses to help tumor cells evade immune surveillance and by negatively affecting the effectiveness of immunotherapies Cellular & Molecular Immunology B cell regulation in cancer and anti-...
60 In addition, CD39+CD73+ adenosine-producing Bregs have also been shown to suppress effector T-cell activation and proliferation by utilizing adenosine and IL-10.66 IL-21-induced CD19+CD38+CD1d+IgM+CD147+ granzyme B-expressing B cells that modulate T-cell responses have also been ...
Drug candidate structures can also be further optimized to improve their effectiveness and bioavailability, including structural modifications, performance prediction and toxicity assessment [50]. Commonly used CADD software programs include: ChemDraw, which a chemical drawing software for molecular structure ...
Perhaps, the ability of pertuzumab to disrupt dimer formation might contribute to its effectiveness in vivo. Although the discrepancy requires further studies, it is possible that the combination of 19H6-Hu with trastuzumab may be efficacious in treating certain types of trastuzumab/pertuzumab resistant...